The family of interferon (IFN) proteins has now more than reached the potential envisioned
by early discovering virologists: IFNs are not only antivirals with a spectrum of clinical …

Mature B lymphocytes (B cells) recognize antigens using their B cell receptor (BCR) and are
activated to become antibody-producing cells. In addition, and integral to the development of …

Newly assembled major histocompatibility complex (MHC) class I molecules, together with
the endoplasmic reticulum chaperone calreticulin, interact with the transporter associated …

Cathepsins have been implicated in the degradation of proteins destined for the MHC class
II processing pathway and in the proteolytic removal of invariant chain (Ii), a critical regulator …

MHC class II molecules display antigenic peptides on cell surfaces for recognition by CD4
(+) T cells. Proteolysis is required in this process both for degradation of invariant chain (Ii) …

Peptide binding to major histocompatibility complex (MHC) dass I molecules occurs in the
endoplasmic reticulum (ER). Efficient peptide binding requires a number of components in …

The endosomes and lysosomes of antigen-presenting cells host the processing and
assembly reactions that result in the display of peptides on major histocompatibility complex …

HLA-DR molecules bind microbial peptides in an endosomal compartment and present
them on the cell surface for CD4 T cell surveillance. HLA-DM plays a critical role in the …

HLA-DM is a major histocompatibility complex (MHC) class II–like molecule that facilitates
antigen processing by catalyzing the exchange of invariant chain–derived peptides (CLIP) …

Tapasin is a resident ER protein believed to be critical for antigen presentation by HLA class
I molecules. We demonstrate that allelic variation in MHC class I molecules influences their …