Haptoglobin (Hp) belongs to the family of acute-phase plasma proteins and represents the
most important plasma detoxifier of hemoglobin (Hb). The basic Hp molecule is a tetrameric …

Haemoglobin is released into the CNS during the breakdown of red blood cells after
intracranial bleeding. Extracellular free haemoglobin is directly neurotoxic. Haemoglobin …

In Brief Prospective identification of individuals with diabetes who are at greatest risk for
developing complications would have considerable public health importance by allowing …

Secondary brain injury after aneurysmal subarachnoid hemorrhage (SAH-SBI) contributes to
poor outcomes in patients after rupture of an intracranial aneurysm. The lack of diagnostic …

The mechanisms underlying poor outcome following subarachnoid haemorrhage (SAH) are
complex and multifactorial. They include early brain injury, spreading depolarisation …

Subarachnoid hemorrhage (SAH) is a complicated clinical syndrome, which is caused by
several kinds of cerebrovascular disorders, with high morbidity, disability and mortality rate …

To improve outcome prediction following subarachnoid haemorrhage (SAH), we sought a
biomarker integrating early brain injury and multiple secondary pathological processes in a …

Delayed cerebral ischaemia (DCI) after aneurysmal subarachnoid haemorrhage (aSAH) is a
major cause of mortality and morbidity. The pathophysiology of DCI after aSAH is thought to …

Haptoglobin (Hp) is a plasma protein involved in clearing extracellular haemoglobin and
regulating inflammation; it exists as two genetic variants (Hp1 and Hp2). In a meta‐analysis …

Objective Cerebral vasospasm (CV) and associated secondary brain injury are major
contributors to death and disability after aneurysmal subarachnoid hemorrhage (aSAH) …