Epidemiological evidence links an individual's susceptibility to chronic disease in adult life to
events during their intrauterine phase of development. Biologically this should not be …

Obesity has reached epidemic proportions and pregnancies in obese mothers have
increased risk for complications including gestational diabetes, hypertensive disorders …

Appropriate in utero growth is essential for offspring development and is a critical contributor
to long-term health. Fetal growth is largely dictated by the availability of nutrients in maternal …

Abnormal fetal growth, both growth restriction and overgrowth, is associated with perinatal
complications and an increased risk of metabolic and cardiovascular disease later in life …

Maternal obesity is associated with placental lipotoxicity, oxidative stress, and inflammation,
where MAPK activity may play a central role. Accordingly, we have previously shown that …

Metabolic disorders have seen an increased prevalence in recent years in developed as
well as developing countries. While it is clear lifestyle choices and habits have contributed to …

The recent and rapid worldwide increase in non-communicable diseases challenges the
assumption that genetic factors are the primary contributors to such diseases. A new concept …

Experimental studies that are relevant to human pregnancy rely on the selection of
appropriate animal models as an important element in experimental design. Consideration …

The placenta is the main determinant of fetal growth and development in utero. It supplies all
the nutrients and oxygen required for fetal growth and secretes hormones that facilitate …

Mammalian embryos have evolved to adjust their organ and tissue development in
response to an atypical environment. This adaptation, called phenotypic plasticity, allows the …