S-nitrosylation is an important mediator of multiple nitric oxide-dependent biological
processes, including eukaryotic cellular events such as macrophage apoptosis and …

Parkinson's disease (PD) is one of the most common progressive neurodegenerative
disorders in modern society. The disease involves many genetic risk factors as well as a …

Rationale: S-nitrosylation (SNO), an oxidative post-translational modification of cysteine
residues, responds to changes in the cardiac redox-environment. Classic biotin-switch …

ERK-dependent signaling is key to many pathways through which extracellular signals are
transduced into cell-fate decisions. One conundrum is the way in which disparate signals …

Nitric oxide has pronounced effects on cellular functions normally associated with the
cytoskeleton, including cell motility, shape, contraction, and mitosis. Protein S‐nitrosylation …

Nitric oxide (• NO) interactions with biological thiols play crucial, but incompletely
determined, roles in vascular signalling and other biological processes. Here, we highlight …

Disturbances in cellular redox balance have been associated with pro-aging mechanisms
and increased risk for various chronic disease states. Multiple lines of evidence indicate that …

Cell death by glutamate excitotoxicity, mediated by N-methyl-d-aspartate (NMDA) receptors,
negatively impacts brain function, including but not limited to hippocampal neurons. The NF …

Reversible chemical modifications of protein cysteine residues by S-nitrosylation and S-
oxidation are increasingly recognized as important regulatory mechanisms for many protein …

Ribonucleotide reductase (RNR) is a multi-subunit enzyme responsible for catalyzing the
rate-limiting step in the production of deoxyribonucleotides essential for DNA synthesis and …