Voltage-gated sodium channels initiate action potentials in nerve, skeletal muscle, and other
electrically excitable cells. Mutations in them cause a wide range of diseases. These …

Mutations in a number of genes encoding voltage‐gated sodium channels cause a variety of
epilepsy syndromes in humans, including genetic (generalized) epilepsy with febrile …

Voltage-gated sodium channel Nav1. 6 plays a crucial role in neuronal firing in the central
nervous system (CNS). Aberrant function of Nav1. 6 may lead to epilepsy and other …

▪ Abstract A variety of isoforms of mammalian voltage-gated sodium channels have been
described. Ten genes encoding sodium channel α subunits have been identified, and nine …

Voltage-dependent sodium channels are uniformly distributed along unmyelinated axons,
but are highly concentrated at nodes of Ranvier in myelinated axons. Here, we show that …

Saltatory conduction of action potentials along myelinated axons depends on the nodes of
Ranvier—small unmyelinated axonal domains where voltage-gated sodium channels are …

The entire length of myelinated axons is organized into a series of polarized domains that
center around nodes of Ranvier. These domains, which are crucial for normal saltatory …

Voltage-gated sodium channels (VGSCs) play a central role in the generation and
propagation of action potentials in neurons and other cells. VGSC modulators have their …

Myelinated axons are organized into a series of specialized domains with distinct molecular
compositions and functions. These domains, which include the node of Ranvier, the flanking …

The mammalian genome contains four voltage-gated sodium channel genes that are
primarily expressed in the central nervous system: SCN1A, SCN2A, SCN3A and SCN8A …