In the last 25 years, a number of animal models, mainly rodents, have been generated with
the goal to mimic cholestatic liver injuries and, thus, to provide in vivo tools to investigate the …

Pruritus is a debilitating symptom of various cholestatic disorders, including primary biliary
cholangitis (PBC), primary sclerosing cholangitis (PSC) and inherited progressive familial …

Chronic liver damage is associated with unique changes in the hemostatic system. Patients
with liver disease often show a precariously rebalanced hemostatic system, which is easily …

Hepatic macrophages play an important role in homeostasis. The functional abnormalities of
hepatic macrophages primarily or secondarily influence chemically induced hepatotoxicity …

Clinical studies have shown that Intrahepatic cholestasis is closely related to intestinal
injury. The gut-liver axis theory suggests that the intestine and liver are closely related, and …

Hepatic macrophages play crucial roles in hepatotoxicity. We investigated
immunophenotypes of macrophages in liver injury induced in rats by thioacetamide (TAA; …

Hepatic macrophages (including Kupffer cells) play a crucial role in the homeostasis and act
as mediators of inflammatory response in the liver. Hepatic macrophages were depleted in …

Exposure of rodents to the xenobiotic α‐naphthylisothiocyanate (ANIT) is an established
model of experimental intrahepatic bile duct injury. Administration of ANIT to mice causes …

The significance of bone morphogenetic protein (BMP)-6 and osteopontin (OPN) in renal
fibrosis is poorly understood. We investigated the expression of BMP-6 and OPN in cisplatin …

Hepatic fibrin deposition has been shown to inhibit hepatocellular injury in mice exposed to
the bile duct toxicant α-naphthylisothiocyanate (ANIT). Degradation of fibrin clots by …