Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …

Mitochondria are unique organelles that are essential for a variety of cellular processes
including energy metabolism, calcium homeostasis, lipid biosynthesis, and apoptosis …

Calcium is an important second messenger involved in intra-and extracellular signaling
cascades and plays an essential role in cell life and death decisions. The Ca 2+ signaling …

Many cellular functions are regulated by calcium (Ca2+) signals that are generated by
different signaling pathways. One of these is the inositol 1, 4, 5-trisphosphate/calcium …

Neurodegenerative disorders are currently incurable devastating diseases which are
characterized by the slow and progressive loss of neurons in specific brain regions …

The mitogen-activated protein kinases (MAPKs) in mammals include c-Jun NH 2-terminal
kinase (JNK), p38 MAPK, and extracellular signal-regulated kinase (ERK). These enzymes …

Cellular Ca 2+ homeostasis is maintained through the integrated and coordinated function
of Ca 2+ transport molecules, Ca 2+ buffers and sensors. These molecules are associated …

Execution of fundamental cellular functions demands regulated protein folding homeostasis.
Endoplasmic reticulum (ER) is an active organelle existing to implement this function by …

More than 2 million people in the United States have myalgic encephalomyelitis/chronic
fatigue syndrome (ME/CFS). We performed targeted, broad-spectrum metabolomics to gain …

Mitochondrial function and specifically its implication in cellular redox/oxidative balance is
fundamental in controlling the life and death of cells, and has been implicated in a wide …