The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD
S Datta, M Cano, K Ebrahimi, L Wang… - Progress in retinal and …, 2017 - Elsevier
The retinal pigment epithelium (RPE) is a highly specialized, unique epithelial cell that
interacts with photoreceptors on its apical side and with Bruch's membrane and the …
interacts with photoreceptors on its apical side and with Bruch's membrane and the …
Age-related macular degeneration: role of oxidative stress and blood vessels
Y Ruan, S Jiang, A Gericke - International journal of molecular sciences, 2021 - mdpi.com
Age-related macular degeneration (AMD) is a common irreversible ocular disease
characterized by vision impairment among older people. Many risk factors are related to …
characterized by vision impairment among older people. Many risk factors are related to …
[HTML][HTML] Global burden of dry age-related macular degeneration: a targeted literature review
NM Schultz, S Bhardwaj, C Barclay, L Gaspar… - Clinical …, 2021 - Elsevier
Purpose Age-related macular degeneration (AMD) is a leading cause of blindness,
particularly in higher-income countries. Although dry AMD accounts for 85% to 90% of AMD …
particularly in higher-income countries. Although dry AMD accounts for 85% to 90% of AMD …
The complement system: a novel therapeutic target for age-related macular degeneration
A Shughoury, DD Sevgi, TA Ciulla - Expert opinion on …, 2023 - Taylor & Francis
Introduction With the recent FDA approvals of pegcetacoplan (SYFOVRE, Apellis
Pharmaceuticals) and avacincaptad pegol (IZERVAY, Astellas Pharmaceuticals) …
Pharmaceuticals) and avacincaptad pegol (IZERVAY, Astellas Pharmaceuticals) …
Age-related macular degeneration revisited: From pathology and cellular stress to potential therapies
M Hadziahmetovic, G Malek - Frontiers in cell and developmental …, 2021 - frontiersin.org
Age-related macular degeneration (AMD) is a neurodegenerative disease of the aging
retina, in which patients experience severe vision loss. Therapies available to patients are …
retina, in which patients experience severe vision loss. Therapies available to patients are …
Ranibizumab (Lucentis) in neovascular age-related macular degeneration: evidence from clinical trials
Background: Neovascular age-related macular degeneration (AMD) has a poor prognosis if
left untreated, frequently resulting in legal blindness. Ranibizumab is approved for treating …
left untreated, frequently resulting in legal blindness. Ranibizumab is approved for treating …
Post-intravitreal anti-VEGF endophthalmitis in the United Kingdom: incidence, features, risk factors, and outcomes
DAM Lyall, A Tey, B Foot, STD Roxburgh, M Virdi… - Eye, 2012 - nature.com
Purpose To describe the incidence, features, management, and risk factors of post-
intravitreal anti-VEGF endophthalmitis (PIAE) in patients undergoing treatment for exudative …
intravitreal anti-VEGF endophthalmitis (PIAE) in patients undergoing treatment for exudative …
Lipids, oxidized lipids, oxidation-specific epitopes, and Age-related Macular Degeneration
JT Handa, M Cano, L Wang, S Datta, T Liu - Biochimica et Biophysica Acta …, 2017 - Elsevier
Abstract Age-related Macular Degeneration (AMD) is the leading cause of blindness among
the elderly in western societies. While antioxidant micronutrient treatment is available for …
the elderly in western societies. While antioxidant micronutrient treatment is available for …
How does the macula protect itself from oxidative stress?
JT Handa - Molecular aspects of medicine, 2012 - Elsevier
Oxidative stress has been hypothesized to contribute to the development of age-related
macular degeneration (AMD), the most common cause of blindness in the United States. At …
macular degeneration (AMD), the most common cause of blindness in the United States. At …
Smoke exposure causes endoplasmic reticulum stress and lipid accumulation in retinal pigment epithelium through oxidative stress and complement activation
K Kunchithapautham, C Atkinson, B Rohrer - Journal of Biological …, 2014 - ASBMB
Age-related macular degeneration (AMD) is a complex disease caused by genetic and
environmental factors, including genetic variants in complement components and smoking …
environmental factors, including genetic variants in complement components and smoking …