Epigenetics and the environmental regulation of the genome and its function

TY Zhang, MJ Meaney - Annual review of psychology, 2010 - annualreviews.org
There are numerous examples in psychology and other disciplines of the enduring effects of
early experience on neural function. In this article, we review the emerging evidence for …

Epigenetic regulation of gene expression in physiological and pathological brain processes

J Gräff, D Kim, MM Dobbin, LH Tsai - Physiological reviews, 2011 - journals.physiology.org
Over the past decade, it has become increasingly obvious that epigenetic mechanisms are
an integral part of a multitude of brain functions that range from the development of the …

Brain-derived neurotrophic factor: a dynamic gatekeeper of neural plasticity

KK Cowansage, JE LeDoux… - Current molecular …, 2010 - ingentaconnect.com
Brain derived neurotrophic factor (BDNF), a member of the neurotrophin family of structurally
related proteins that promote neuronal differentiation and survival during development [1, 2] …

Epigenetic regulation of the BDNF gene: implications for psychiatric disorders

F Boulle, DLA Van Den Hove, SB Jakob… - Molecular …, 2012 - nature.com
Abnormal brain-derived neurotrophic factor (BDNF) signaling seems to have a central role in
the course and development of various neurological and psychiatric disorders. In addition …

The potential of HDAC inhibitors as cognitive enhancers

J Gräff, LH Tsai - Annual review of pharmacology and toxicology, 2013 - annualreviews.org
Histone acetylation is a prominent epigenetic modification of the central nervous system that
is unequivocally associated with an increase in the rate of gene transcription. Because gene …

Epigenetic modification of hippocampal Bdnf DNA in adult rats in an animal model of post-traumatic stress disorder

TL Roth, PR Zoladz, JD Sweatt, DM Diamond - Journal of psychiatric …, 2011 - Elsevier
Epigenetic alterations of the brain-derived neurotrophic factor (Bdnf) gene have been linked
with memory, stress, and neuropsychiatric disorders. Here we examined whether there was …

Fear extinction and BDNF: translating animal models of PTSD to the clinic

R Andero, KJ Ressler - Genes, Brain and Behavior, 2012 - Wiley Online Library
Brain‐derived neurotrophic factor (BDNF) is the most studied neurotrophin involved in
synaptic plasticity processes that are required for long‐term learning and memory …

How the epigenome integrates information and reshapes the synapse

RR Campbell, MA Wood - Nature Reviews Neuroscience, 2019 - nature.com
In the past few decades, the field of neuroepigenetics has investigated how the brain
encodes information to form long-lasting memories that lead to stable changes in behaviour …

The epigenetics of social adversity in early life: implications for mental health outcomes

PO McGowan, M Szyf - Neurobiology of disease, 2010 - Elsevier
An organism's behavioral and physiological and social milieu influence and are influenced
by the epigenome, which is composed predominantly of chromatin and the covalent …

Stress and trauma: BDNF control of dendritic-spine formation and regression

MR Bennett, J Lagopoulos - Progress in neurobiology, 2014 - Elsevier
Chronic restraint stress leads to increases in brain derived neurotrophic factor (BDNF)
mRNA and protein in some regions of the brain, eg the basal lateral amygdala (BLA) but …