Several neurodegenerative disorders involve impaired neurotransmission, and
glutamatergic neurotransmission sets a prototypical example. Glutamate is a predominant …

Astrocytes are essential for normal brain development and functioning. They respond to
brain injury and disease through a process referred to as reactive astrogliosis, where the …

The TREM2–DAP12 receptor complex sustains microglia functions. Heterozygous
hypofunctional TREM2 variants impair microglia, accelerating late-onset Alzheimer's …

Traumatic brain injury (TBI) results when external physical forces impact the head with
sufficient intensity to cause damage to the brain. TBI can be mild, moderate, or severe and …

Frontotemporal lobar degeneration with tau (FTLD-tau) is a group of tauopathies that
underlie∼ 50% of FTLD cases. Identification of genetic risk variants related to …

Neurological disorders have been linked to a defective blood–brain barrier (BBB), with
dysfunctions triggered by stage-specific disease mechanisms, some of these being …

Reactive astrogliosis is a reaction of astrocytes to disturbed homeostasis in the central
nervous system (CNS), accompanied by changes in astrocyte numbers, morphology, and …

Both astrocytic and microglial functions have been extensively investigated in healthy
subjects and neurodegenerative diseases. For astrocytes, not only various sub-types were …

Neuroinflammation is one of the postulated mechanisms for Pb neurotoxicity. However, the
exact molecular mechanisms responsible for its pro-inflammatory effect are not fully …

Reactive astrocytes are associated with neuroinflammation and cognitive decline in diverse
neuropathologies; however, the underlying mechanisms are unclear. We used optogenetic …