PINTology: A short history of the lncRNA LINC‐PINT in different diseases
LINC‐PINT is a p53‐induced long intergenic noncoding transcript that plays a crucial role in
many diseases, especially cancer. This long noncoding RNA (lncRNA) gene produces in …
many diseases, especially cancer. This long noncoding RNA (lncRNA) gene produces in …
Interindividual variation in human cortical cell type abundance and expression
Single-cell transcriptomic studies have identified a conserved set of neocortical cell types
from small postmortem cohorts. We extended these efforts by assessing cell type variation …
from small postmortem cohorts. We extended these efforts by assessing cell type variation …
Genetic Determinants of Vascular Dementia
Vascular dementia (VaD) is a prevalent form of cognitive impairment with underlying
vascular etiology. In this review, we examine recent genetic advancements in our …
vascular etiology. In this review, we examine recent genetic advancements in our …
[HTML][HTML] The big picture of neurodegeneration: a meta study to extract the essential evidence on neurodegenerative diseases in a network-based approach
The common features of all neurodegenerative diseases, including Alzheimer's disease,
Parkinson's disease, Amyotrophic Lateral Sclerosis, and Huntington's disease, are the …
Parkinson's disease, Amyotrophic Lateral Sclerosis, and Huntington's disease, are the …
The shared genetic architecture of modifiable risk for Alzheimer's disease: a genomic structural equation modelling study
Targeting modifiable risk factors may help to prevent Alzheimer's disease (AD), but the
pathways by which these risk factors influence AD risk remain incompletely understood. We …
pathways by which these risk factors influence AD risk remain incompletely understood. We …
Control of hippocampal synaptic plasticity by microglia–dendrite interactions depends on genetic context in mouse models of Alzheimer's disease
SE Heuer, KJ Keezer, AA Hewes… - Alzheimer's & …, 2024 - Wiley Online Library
INTRODUCTION Human data suggest susceptibility and resilience to features of Alzheimer's
disease (AD) such as microglia activation and synaptic dysfunction are under genetic …
disease (AD) such as microglia activation and synaptic dysfunction are under genetic …
Whole genome sequencing based analysis of inflammation biomarkers in the Trans-Omics for Precision Medicine (TOPMed) consortium
Inflammation biomarkers can provide valuable insight into the role of inflammatory
processes in many diseases and conditions. Sequencing based analyses of such …
processes in many diseases and conditions. Sequencing based analyses of such …
[HTML][HTML] Genome-wide association study of brain biochemical phenotypes reveals distinct genetic architecture of Alzheimer's disease related proteins
SR Oatman, JS Reddy, Z Quicksall… - Molecular …, 2023 - Springer
Background Alzheimer's disease (AD) is neuropathologically characterized by amyloid-beta
(Aβ) plaques and neurofibrillary tangles. The main protein components of these hallmarks …
(Aβ) plaques and neurofibrillary tangles. The main protein components of these hallmarks …
[HTML][HTML] Genetic context controls early microglia-synaptic interactions in mouse models of Alzheimer's disease
SE Heuer, KJ Keezer, AA Hewes, KD Onos… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Common features of Alzheimer's disease (AD) include amyloid pathology, microglia
activation and synaptic dysfunction, however, the causal relationships amongst them …
activation and synaptic dysfunction, however, the causal relationships amongst them …
[Retracted] Study on Circulating lncRNA Expression Profile in Patients with Cerebral Infarction
M Li, C Luo, P Xu, Y Jin - Disease Markers, 2022 - Wiley Online Library
To analyze the difference of circulating lncRNA expression profile between the healthy
control group and cerebral infarction (CI) patients and to study the epigenetic pathogenesis …
control group and cerebral infarction (CI) patients and to study the epigenetic pathogenesis …