Although the cytotoxic effects of viruses are usually viewed in terms of pathogenicity, it is
possible to harness this activity for therapeutic purposes. Viral genomes are highly versatile …

Introduction 3. The E1A proteins 3.1. Early findings 3.2. Targeting the pRb checkpoint by
E1A 3.2. 1. pRb 3.2. 2. pRb family members 3.3. Targeting cyclin-Cdks by E1A 3.4. E1A …

The JAK-STAT signalling pathway regulates cellular processes like cell division, cell death
and immune regulation. Dysregulation has been identified in solid tumours and STAT3 …

We have constructed a new capsid-modified adenovirus (Ad) vector that specifically
replicates in tumor cells and expresses TNF-related apoptosis-inducing ligand (TRAIL). The …

Over the past few years there have been a number of interesting advances in our
understanding of the functions encoded by the adenovirus early transcription unit 4 (Ad E4) …

Background & aims: Pancreatic cancer is one of the most aggressive human malignancies.
Conditionally replicative adenoviruses (CRAds) have shown some promise in the treatment …

Exploiting the lytic life cycle of viruses has gained recent attention as an anticancer strategy
(oncolysis). To explore the utility of adenovirus (Ad)-mediated oncolysis for …

Advances in gene modification and viral therapy have led to the development of a variety of
vectors in several viral families that are capable of replication specifically in tumor cells …

Human papillomaviruses (HPV) cause malignant epithelial cancers including cervical
carcinoma, non-melanoma skin and head and neck cancer. They drive tumor development …

Abnormalities in the control and execution of apoptosis are seen in many malignancies,
including ovarian carcinoma. Many of these abnormalities involve the mitochondrial …