Targeted enrichment strategies for next‐generation plant biology
• Premise of the study: The dramatic advances offered by modern DNA sequencers continue
to redefine the limits of what can be accomplished in comparative plant biology. Even with …
to redefine the limits of what can be accomplished in comparative plant biology. Even with …
Next is now: new technologies for sequencing of genomes, transcriptomes, and beyond
The sudden availability of DNA sequencing technologies that rapidly produce vast amounts
of sequence information has triggered a paradigm shift in genomics, enabling massively …
of sequence information has triggered a paradigm shift in genomics, enabling massively …
Systematic comparison of three genomic enrichment methods for massively parallel DNA sequencing
JK Teer, LL Bonnycastle, PS Chines… - Genome …, 2010 - genome.cshlp.org
Massively parallel DNA sequencing technologies have greatly increased our ability to
generate large amounts of sequencing data at a rapid pace. Several methods have been …
generate large amounts of sequencing data at a rapid pace. Several methods have been …
Fast-forward genetics enabled by new sequencing technologies
K Schneeberger, D Weigel - Trends in plant science, 2011 - cell.com
New sequencing technologies are dramatically accelerating progress in forward genetics,
and the use of such methods for the rapid identification of mutant alleles will be soon routine …
and the use of such methods for the rapid identification of mutant alleles will be soon routine …
Revisiting Mendelian disorders through exome sequencing
CS Ku, N Naidoo, Y Pawitan - Human genetics, 2011 - Springer
Over the past several years, more focus has been placed on dissecting the genetic basis of
complex diseases and traits through genome-wide association studies. In contrast …
complex diseases and traits through genome-wide association studies. In contrast …
RAD cap: sequence capture of dual‐digest RAD seq libraries with identifiable duplicates and reduced missing data
Molecular ecologists seek to genotype hundreds to thousands of loci from hundreds to
thousands of individuals at minimal cost per sample. Current methods, such as restriction …
thousands of individuals at minimal cost per sample. Current methods, such as restriction …
Delineating the genetic heterogeneity of ALS using targeted high-throughput sequencing
Background Over 100 genes have been implicated in the aetiology of amyotrophic lateral
sclerosis (ALS). A detailed understanding of their independent and cumulative contributions …
sclerosis (ALS). A detailed understanding of their independent and cumulative contributions …
Targeted sequencing for gene discovery and quantification using RNA CaptureSeq
RNA sequencing (RNAseq) samples the majority of expressed genes infrequently, owing to
the large size, complex splicing and wide dynamic range of eukaryotic transcriptomes. This …
the large size, complex splicing and wide dynamic range of eukaryotic transcriptomes. This …
Development of genome-wide SNP assays for rice
Single nucleotide polymorphisms (SNPs) are the most abundant form of genetic variation in
eukaryotic genomes. SNPs may be functionally responsible for specific traits or phenotypes …
eukaryotic genomes. SNPs may be functionally responsible for specific traits or phenotypes …
Highly-multiplexed barcode sequencing: an efficient method for parallel analysis of pooled samples
Next-generation sequencing has proven an extremely effective technology for molecular
counting applications where the number of sequence reads provides a digital readout for …
counting applications where the number of sequence reads provides a digital readout for …