The goal of sequencing the entire human genome for $1000 is almost in sight. However, the
total costs including DNA sequencing, data management, and analysis to yield a clear data …

Abstract Background Mobile elements (MEs) are diverse, common and dynamic inhabitants
of nearly all genomes. ME transposition generates a steady stream of polymorphic genetic …

Disclosed herein is a system and method for increasing the fidelity of measured genetic
data, for making allele calls, and for determining the state of aneuploidy, in one or a small …

One approach for high-throughput population-based sequencing of targeted intervals in the
human genome is to amplify the regions using long-range PCR (LR-PCR) followed by …

• Premise of the study: We explored a targeted enrichment strategy to facilitate rapid and low‐
cost next‐generation sequencing (NGS) of numerous complete plastid genomes from across …

The present disclosure provides methods for determining the ploidy status of a chromosome
in a gestating fetus from genotypic data measured from a mixed sample of DNA comprising …

Background The barcoding of next generation sequencing libraries has become an
essential part of the experimental design. Barcoding not only allows the sequencing of more …

Massively parallel DNA sequencing is capable of sequencing tens of millions of DNA
fragments at the same time. However, sequence bias in the initial cycles, which are used to …

Error rates in massively parallel sequencing instruments are generally too high to allow
confident identification of rare variants. An approach that can substantially increase the …

Multilocus sequence typing (MLST) is a widely used system for typing microorganisms by
sequence analysis of housekeeping genes. The main advantage of MLST in comparison to …