Inherited retinal diseases (IRD) are a leading cause of blindness in the working age
population and children. The scope of this review is to familiarise clinicians and scientists …

Glaucoma is the result of the gradual death of retinal ganglion cells (RGCs) whose axons
form the optic nerve. Elevated intraocular pressure (IOP) is a major risk factor that …

Lipid nanoparticle (LNP)–based mRNA delivery holds promise for the treatment of inherited
retinal degenerations. Currently, LNP-mediated mRNA delivery is restricted to the retinal …

CRISPR-Cas-based genome editing technologies could, in principle, be used to treat a wide
variety of inherited diseases, including genetic disorders of vision. Programmable CRISPR …

Genome-editing technologies have ushered in a new era in gene therapy, providing novel
therapeutic strategies for a wide range of diseases, including both genetic and nongenetic …

Achromatopsia (ACHM), also known as rod monochromatism or total color blindness, is an
autosomal recessively inherited retinal disorder that affects the cones of the retina, the type …

Purpose Stem cell therapy is a promising therapeutic approach for inherited retinal diseases
(IRDs). This study aims to quantitatively examine the effectiveness and safety of stem cell …

Inherited retinal diseases (IRDs) are a genetically and phenotypically heterogeneous group
of genetic eye disorders. There are more than 300 disease entities, and together this group …

Purpose This study aimed to systematically review and summarize gene therapy treatment
for monogenic retinal and optic nerve diseases. Methods This review was prospectively …

PURPOSE To investigate the natural disease course of retinal dystrophies associated with
crumbs cell polarity complex component 1 (CRB1) and identify clinical end points for future …