Immunology and immunotherapy of cholangiocarcinoma

TF Greten, R Schwabe, N Bardeesy, L Ma… - Nature Reviews …, 2023 - nature.com
Cholangiocarcinoma is the second most common primary liver cancer. Its incidence is low in
the Western world but is rising globally. Surgery, chemotherapy and radiation therapy have …

[HTML][HTML] The role of tumor-infiltrating lymphocytes in cholangiocarcinoma

D Liu, LR Heij, Z Czigany, E Dahl, SA Lang… - Journal of Experimental …, 2022 - Springer
Cholangiocarcinoma (CCA) is the second most common primary liver cancer and
associated with a dismal prognosis due to the lack of an efficient systemic therapy. In …

[HTML][HTML] Toripalimab combined with lenvatinib and GEMOX is a promising regimen as first-line treatment for advanced intrahepatic cholangiocarcinoma: a single …

GM Shi, XY Huang, D Wu, HC Sun, F Liang… - Signal transduction and …, 2023 - nature.com
Advanced intrahepatic cholangiocarcinoma (ICC) has a dismal prognosis. Here, we report
the efficacy and safety of combining toripalimab, lenvatinib, and gemcitabine plus oxaliplatin …

[HTML][HTML] Lacking immunotherapy biomarkers for biliary tract cancer: a comprehensive systematic literature review and meta-analysis

G Frega, FP Cossio, JM Banales, V Cardinale… - Cells, 2023 - mdpi.com
Background: Immunotherapy has recently been incorporated into the spectrum of biliary tract
cancer (BTC) treatment. The identification of predictive response biomarkers is essential in …

[HTML][HTML] Immune microenvironment of cholangiocarcinoma: Biological concepts and treatment strategies

X Yu, L Zhu, T Wang, J Chen - Frontiers in Immunology, 2023 - frontiersin.org
Cholangiocarcinoma is characterized by a poor prognosis with limited treatment and
management options. Chemotherapy using gemcitabine with cisplatin is the only available …

[HTML][HTML] Neoadjuvant and adjuvant therapy in intrahepatic cholangiocarcinoma

X Chen, J Du, J Huang, Y Zeng… - Journal of Clinical and …, 2022 - ncbi.nlm.nih.gov
Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer and
causes major economic and health burdens throughout the world. Although the incidence of …

Tumor immune microenvironment and the current immunotherapy of cholangiocarcinoma

S Yang, R Zou, Y Dai, Y Hu, F Li… - … Journal of Oncology, 2023 - spandidos-publications.com
Cholangiocarcinoma (CCA) is a highly heterogeneous malignancy originating from the
epithelial system of the bile ducts, and its incidence in recent years is steadily increasing …

[HTML][HTML] Autoimmune pancreatitis and pancreatic cancer: Epidemiological aspects and immunological considerations

D Poddighe - World Journal of Gastroenterology, 2021 - ncbi.nlm.nih.gov
Ordinary chronic pancreatitis is a well-known risk factor for pancreatic cancer, whereas such
an association with autoimmune pancreatitis (AIP) is widely debated. Due to the rarity of the …

[HTML][HTML] Targeting tumor microenvironment for cholangiocarcinoma: Opportunities for precision medicine

R Carloni, A Rizzo, AD Ricci, A Di Federico… - Translational …, 2022 - Elsevier
Systemic treatments (eg, chemotherapy and targeted therapies) have limited efficacy for
patients with locally advanced–unresectable–and metastatic cholangiocarcinoma (CCA) …

PD-L1 expression on immune cells, but not on tumor cells, is a favorable prognostic factor for patients with intrahepatic cholangiocarcinoma

LP Mocan, R Craciun, C Grapa, CS Melincovici… - Cancer Immunology …, 2023 - Springer
Cholangiocarcinoma, the second most common liver malignancy, after hepatocarcinoma is
highly aggressive and usually diagnosed in advanced cases. In the era of personalized …