Regulatory roles of copper metabolism and cuproptosis in human cancers

Z Wang, D Jin, S Zhou, N Dong, Y Ji, P An… - Frontiers in …, 2023 - frontiersin.org
Copper is an essential micronutrient for human body and plays a vital role in various
biological processes including cellular respiration and free radical detoxification. Generally …

Copper metabolism and cuproptosis in human malignancies: Unraveling the complex interplay for therapeutic insights

KM Abdullah, JB Kaushal, S Takkar, G Sharma… - Heliyon, 2024 - cell.com
Copper, a vital trace element, orchestrates diverse cellular processes ranging from energy
production to antioxidant defense and angiogenesis. Copper metabolism and cuproptosis …

Insights into prognosis and immune infiltration of cuproptosis-related genes in breast cancer

T Huang, Y Liu, J Li, B Shi, Z Shan, Z Shi… - Frontiers in …, 2022 - frontiersin.org
Introduction Breast cancer (BC) has been ranking first in incidence and the leading cause of
death among female cancers worldwide based on the latest report. Regulated cell death …

A prognostic signature of cuproptosis and TCA-related genes for hepatocellular carcinoma

Q Zhang, L Ma, H Zhou, Y Zhou, S Liu, Q Li - Frontiers in Oncology, 2022 - frontiersin.org
Background Hepatocellular carcinoma (HCC) is the most common malignant tumor of the
liver. Cuproptosis is a newly defined form of cell death. Copper ion induces cell death by …

Morphology-based deep learning enables accurate detection of senescence in mesenchymal stem cell cultures

L He, M Li, X Wang, X Wu, G Yue, T Wang, Y Zhou… - BMC biology, 2024 - Springer
Background Cell senescence is a sign of aging and plays a significant role in the
pathogenesis of age-related disorders. For cell therapy, senescence may compromise the …

Cuproptosis-related lncRNA gene signature establishes a prognostic model of gastric adenocarcinoma and evaluate the effect of antineoplastic drugs

H Tu, Q Zhang, L Xue, J Bao - Genes, 2022 - mdpi.com
Background: One of the most frequent malignancies of the digestive system is stomach
adenocarcinoma (STAD). Recent research has demonstrated how cuproptosis (copper …

Identification and validation of cuproptosis-related LncRNA signatures as a novel prognostic model for head and neck squamous cell cancer

X Liu, W Cheng, H Li, Y Song - Cancer Cell International, 2022 - Springer
Background Head and neck squamous cell cancer (HNSCC) is a common malignant
cancer. We aimed to explore prognostic cuproptosis-related lncRNAs (CRLs) and prognostic …

Cuproptosis-and m6A-Related lncRNAs for prognosis of hepatocellular carcinoma

Y Zhu, JK Tan, JA Goon - Biology, 2023 - mdpi.com
Simple Summary Hepatocellular carcinoma (HCC) is known for its poor prognosis, but the
markers for prognosis still remain unclear to date. This study focused on the long non-coding …

Development and validation of a cuproptosis-associated prognostic model for diffuse large B-cell lymphoma

B Zhang, T Zhang, Z Zheng, Z Lin, Q Wang… - Frontiers in …, 2023 - frontiersin.org
Diffuse large B-cell lymphoma (DLBCL) is a highly heterogeneous disease. Therefore, more
reliable biomarkers are required to better predict the prognosis of DLBCL. Cuproptosis is a …

Analysis of the correlation between non-alcoholic fatty liver disease and the risk of colorectal neoplasms

S Ye, Y Liu, T Zhang, H Feng, Y Liu, L Ma - Frontiers in Pharmacology, 2022 - frontiersin.org
This study aims at assessing the potential association between non-alcoholic fatty liver
disease (NAFLD) and colorectal neoplasms (CRN). PubMed, Cochrane Library, and …