Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder, characterized by
the formation, aggregation and accumulation of amyloid beta, perturbed metal (copper, iron …

Alzheimer's disease, a major and increasing global health challenge, is an irreversible,
progressive form of dementia, associated with an ongoing decline of brain functioning. The …

Neurodegenerative Diseases (NDs) are progressive multifactorial neurological pathologies
related to neuronal impairment and functional loss from different brain regions. Currently, no …

Neuroinflammation and cholinergic deficit are key detrimental processes involved in
Alzheimer's disease. Hence, in the search for novel and effective treatment strategies, the …

Introduction: Alzheimer's disease (AD), the most common type of dementia among older
adults, is a chronic neurodegenerative pathology that causes a progressive loss of cognitive …

We synthesized conjugates of tacrine with 1, 2, 4-thiadiazole derivatives linked by two
different spacers, pentylaminopropene (compounds 4) and pentylaminopropane …

The discovery and development of multitarget-directed ligands (MTDLs) is a promising
strategy to find new therapeutic solutions for neurodegenerative diseases (NDs), in …

Despite tremendous research efforts at every level, globally, there is still a lack of effective
drugs for the treatment of Alzheimer′ s disease (AD). The biochemical mechanisms of this …

Emerging evidence suggests a potential role for natural killer (NK) cells in
neurodegenerative diseases, such as multiple sclerosis, Alzheimer's disease, Parkinson's …

Mercury (Hg), which is a non-essential element, is considered a highly toxic pollutant for
biological systems even when present at trace levels. Elevated Hg exposure with the …