Management of oxidative stress and other pathologies in Alzheimer's disease
Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder, characterized by
the formation, aggregation and accumulation of amyloid beta, perturbed metal (copper, iron …
the formation, aggregation and accumulation of amyloid beta, perturbed metal (copper, iron …
Alzheimer's disease pharmacotherapy in relation to cholinergic system involvement
GD Stanciu, A Luca, RN Rusu, V Bild… - Biomolecules, 2019 - mdpi.com
Alzheimer's disease, a major and increasing global health challenge, is an irreversible,
progressive form of dementia, associated with an ongoing decline of brain functioning. The …
progressive form of dementia, associated with an ongoing decline of brain functioning. The …
Molecular hybridization as a tool in the design of multi-target directed drug candidates for neurodegenerative diseases
VS Gontijo, FPD Viegas, CJC Ortiz… - Current …, 2020 - ingentaconnect.com
Neurodegenerative Diseases (NDs) are progressive multifactorial neurological pathologies
related to neuronal impairment and functional loss from different brain regions. Currently, no …
related to neuronal impairment and functional loss from different brain regions. Currently, no …
Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase
ED AlFadly, PA Elzahhar, A Tramarin, S Elkazaz… - European journal of …, 2019 - Elsevier
Neuroinflammation and cholinergic deficit are key detrimental processes involved in
Alzheimer's disease. Hence, in the search for novel and effective treatment strategies, the …
Alzheimer's disease. Hence, in the search for novel and effective treatment strategies, the …
Developments with multi-target drugs for Alzheimer's disease: An overview of the current discovery approaches
JF González, AR Alcántara, AL Doadrio… - Expert opinion on …, 2019 - Taylor & Francis
Introduction: Alzheimer's disease (AD), the most common type of dementia among older
adults, is a chronic neurodegenerative pathology that causes a progressive loss of cognitive …
adults, is a chronic neurodegenerative pathology that causes a progressive loss of cognitive …
Conjugates of tacrine and 1, 2, 4-thiadiazole derivatives as new potential multifunctional agents for Alzheimer's disease treatment: Synthesis, quantum-chemical …
GF Makhaeva, NV Kovaleva, NP Boltneva… - Bioorganic …, 2020 - Elsevier
We synthesized conjugates of tacrine with 1, 2, 4-thiadiazole derivatives linked by two
different spacers, pentylaminopropene (compounds 4) and pentylaminopropane …
different spacers, pentylaminopropene (compounds 4) and pentylaminopropane …
The chemistry toolbox of multitarget-directed ligands for Alzheimer's disease
The discovery and development of multitarget-directed ligands (MTDLs) is a promising
strategy to find new therapeutic solutions for neurodegenerative diseases (NDs), in …
strategy to find new therapeutic solutions for neurodegenerative diseases (NDs), in …
Perspectives for new and more efficient multifunctional ligands for Alzheimer′ s disease therapy
A Zagórska, A Jaromin - Molecules, 2020 - mdpi.com
Despite tremendous research efforts at every level, globally, there is still a lack of effective
drugs for the treatment of Alzheimer′ s disease (AD). The biochemical mechanisms of this …
drugs for the treatment of Alzheimer′ s disease (AD). The biochemical mechanisms of this …
The role of CD56bright NK cells in neurodegenerative disorders
C Rodriguez-Mogeda, CMJ van Ansenwoude… - Journal of …, 2024 - Springer
Emerging evidence suggests a potential role for natural killer (NK) cells in
neurodegenerative diseases, such as multiple sclerosis, Alzheimer's disease, Parkinson's …
neurodegenerative diseases, such as multiple sclerosis, Alzheimer's disease, Parkinson's …
Insights into the potential role of mercury in Alzheimer's disease
Mercury (Hg), which is a non-essential element, is considered a highly toxic pollutant for
biological systems even when present at trace levels. Elevated Hg exposure with the …
biological systems even when present at trace levels. Elevated Hg exposure with the …