[HTML][HTML] The development of maillard reaction, and advanced glycation end product (AGE)-receptor for AGE (RAGE) signaling inhibitors as novel therapeutic …

CY Shen, CH Lu, CH Wu, KJ Li, YM Kuo, SC Hsieh… - Molecules, 2020 - mdpi.com
Advanced glycation end products (AGEs) are generated by nonenzymatic modifications of
macromolecules (proteins, lipids, and nucleic acids) by saccharides (glucose, fructose, and …

Old wine in new bottles: Kaempferol is a promising agent for treating the trilogy of liver diseases

X Xiao, Q Hu, X Deng, K Shi, W Zhang, Y Jiang… - Pharmacological …, 2022 - Elsevier
As a source of various compounds, natural products have long been important and valuable
for drug development. Kaempferol (KP) is the most common flavonol with bioactive activity …

[HTML][HTML] Resveratrol reestablishes mitochondrial quality control in myocardial ischemia/reperfusion injury through Sirt1/Sirt3-Mfn2-Parkin-PGC-1α pathway

M Zheng, Y Bai, X Sun, R Fu, L Liu, M Liu, Z Li… - Molecules, 2022 - mdpi.com
Resveratrol is a natural polyphenol found in various plants. It has been widely studied on
cardiovascular disorders. It is known that resveratrol can activate Sirtuin proteins and …

[HTML][HTML] Insights into fourth generation selective inhibitors of (C797S) EGFR mutation combating non-small cell lung cancer resistance: a critical review

MA Mansour, AM AboulMagd, SH Abbas… - RSC …, 2023 - pubs.rsc.org
Lung cancer is the second most common cause of morbidity and mortality among cancer
types worldwide, with non-small cell lung cancer (NSCLC) representing the majority of most …

[HTML][HTML] Resveratrol improves Bnip3-related mitophagy and attenuates high-fat-induced endothelial dysfunction

C Li, Y Tan, J Wu, Q Ma, S Bai, Z Xia, X Wan… - Frontiers in Cell and …, 2020 - frontiersin.org
Statin treatment reduces cardiovascular risk. However, individuals with well-controlled low-
density lipoprotein (LDL) levels may remain at increased risk owing to persistent high …

An overview of the pharmacological activities of scopoletin against different chronic diseases

D Parama, S Girisa, E Khatoon, A Kumar… - Pharmacological …, 2022 - Elsevier
Chronic diseases are considered a major public health concern worldwide, and most of
these diseases like cancer, cardiovascular, metabolic, and neurological disorders occur due …

Biological effects and mechanisms of matrine and other constituents of Sophora flavescens in colorectal cancer

MH Chen, YY Gu, AL Zhang, DM Sze, SL Mo… - Pharmacological …, 2021 - Elsevier
Abstract The plant Sophora flavescens Ait. has been used in the clinical management of
colorectal cancer (CRC). Its constituent compounds, notably the alkaloids matrine …

Recent advances of novel fourth generation EGFR inhibitors in overcoming C797S mutation of lung cancer therapy

L Xu, B Xu, J Wang, Y Gao, X He, T Xie… - European Journal of …, 2023 - Elsevier
Lung cancer is the second place among the global cancer population in term of the
morbidity and mortality, while non-small cell lung cancer (NSCLC) accounts for the largest …

[HTML][HTML] Natural products modulate cell apoptosis: a promising way for treating endometrial cancer

X Zhou, Y Zeng, J Huang - Frontiers in Pharmacology, 2023 - frontiersin.org
Endometrial cancer (EC) is a prevalent epithelial malignancy in the uterine corpus's
endometrium and myometrium. Regulating apoptosis of endometrial cancer cells has been …

[HTML][HTML] Pharmacokinetics and biological activity of cucurbitacins

EE Delgado-Tiburcio, J Cadena-Iñiguez… - Pharmaceuticals, 2022 - mdpi.com
Cucurbitacins are a class of secondary metabolites initially isolated from the Cucurbitaceae
family. They are important for their analgesic, anti-inflammatory, antimicrobial, antiviral, and …