Covering: 2015 up to 2022 (Feb) Silymarin, an extract of milk thistle (Silybum marianum)
fruits, has been used in various medicinal applications since ancient times. A major …

Silybum marianum (SM), a well-known plant used as both a medicine and a food, has been
widely used to treat various diseases, especially hepatic diseases. The seeds and fruits of …

A large number of diverse mechanisms that lead to cytoprotection have been described to
date. Perhaps, not surprisingly, the role of mitochondria in these phenomena is notable. In …

(1) Background: Ellagitannins are natural products occurring in pomegranate and walnuts.
They are hydrolyzed in the gut to release ellagic acid, which is further metabolized by the …

Non-alcoholic fatty liver disease (NAFLD) has become one of the most common chronic liver
diseases worldwide, and its prevalence is still growing rapidly. However, the efficient …

Mitochondria are central organelles in the homeostasis of the cardiovascular system via the
integration of several physiological processes, such as ATP generation via oxidative …

This review focuses on the specific biological effects of optically pure silymarin flavo-
nolignans, mainly silybins A and B, isosilybins A and B, silychristins A and B, and their 2, 3 …

Oxidative stress plays an important role in the pathogenesis of nonalcoholic fatty liver
disease (NAFLD). Baicalin has been shown to exert protective effects in various liver …

Background Silibinin (SIL) has been extensively studied for its therapeutic effects on various
liver diseases. However, its effect on acute liver injury was limited for poor solubility and low …

Although the lipophilic triphenylphosphonium (TPP+) cation is widely used to target
antioxidants to mitochondria, TPP+-based derivatives have shown cytotoxicity in several …