Abstract In 1959, Niels Lassen illustrated the cerebral autoregulation curve in the classic
review article entitled Cerebral Blood Flow and Oxygen Consumption in Man. This concept …

Neurovascular coupling reflects the close temporal and regional linkage between neural
activity and cerebral blood flow. Although providing mechanistic insight, our understanding …

Derangements in cerebrovascular structure and function can impair cognitive performance
throughout ageing and in cardiometabolic disease states, thus increasing dementia risk …

Transcranial Doppler (TCD) ultrasound provides rapid, noninvasive, real-time measures of
cerebrovascular function. TCD can be used to measure flow velocity in the basal arteries of …

Visual impairment intracranial pressure (VIIP) syndrome is considered an unexplained
major risk for future long-duration spaceflight. NASA recently redefined this syndrome as …

Key points• The partial pressures of arterial carbon dioxide () and oxygen () has a marked
influence on brain blood flow.• It is unclear if the larger brain arteries are also sensitive to …

The increasing number of older adults has seen a corresponding growth in those affected by
neurovascular diseases, including stroke and dementia. Since cures are currently …

This review highlights the influence of oxygen (O2) availability on cerebral blood flow (CBF).
Evidence for reductions in O2 content (CaO2) rather than arterial O2 tension (PaO2) as the …

Intracranial pressure (ICP) monitoring is a staple of neurocritical care. The most commonly
used current methods of monitoring in the acute setting include fluid-based systems …

Decreased cerebrovascular blood flow and function are associated with lower cognitive
functioning and increased risk of neurodegenerative diseases. Prolonged sitting impairs …