Aims Routine genetic testing in Dilated Cardiomyopathy (DCM) has recently become reality
using Next-Generation Sequencing. Several studies have explored the relationship between …

The calcium pump (aka Ca 2+-ATPase or SERCA) is a membrane transport protein
ubiquitously found in the endoplasmic reticulum (ER) of all eukaryotic cells. As a calcium …

Cardiomyocyte function depends on coordinated movements of calcium into and out of the
cell and the proper delivery of ATP to energy-utilizing enzymes. Defects in calcium-handling …

BACKGROUND: The p. Arg14del variant of the PLN (phospholamban) gene causes
cardiomyopathy, leading to severe heart failure. Calcium handling defects and perinuclear …

Cardiovascular diseases are the leading causes of mortality worldwide. Among them,
hypertension and its pathological complications pose a major risk for the development of …

The sarco-endoplasmic reticulum calcium ATPase (SERCA) is responsible for maintaining
calcium homeostasis in all eukaryotic cells by actively transporting calcium from the cytosol …

The sarco-plasmic reticulum calcium pump (SERCA) plays a critical role in the contraction-
relaxation cycle of muscle. In cardiac muscle, SERCA is regulated by the inhibitor …

The recently-discovered single-span transmembrane proteins endoregulin (ELN), dwarf
open reading frame (DWORF), myoregulin (MLN), and another-regulin (ALN) are reported to …

Arrhythmogenic cardiomyopathy affects significant number of patients worldwide and is
characterized by life-threatening ventricular arrhythmias and sudden cardiac death …

The sarco (endo) plasmic reticulum calcium ATPase (SERCA) is regulated in a tissue-
dependent manner via interaction with the short integral membrane proteins …