Hematopoietic stem cells (HSC) and T cells are intimately related, lineage-dependent cell
populations that are extensively used as therapeutic products for the treatment of …

The severe harm of depression to human health and life has attracted global attention, but
the exact mechanism is not yet known due to the complicated pathogenesis. The existing …

T cell–retargeting therapies have transformed the therapeutic landscape for hematologic
diseases. T cell–dependent bispecific antibodies (TDB) function as conditional agonists that …

The efficacy of adoptive T cell therapy (ACT) for the treatment of solid tumors remains
challenging. In addition to the poor infiltration of effector T (Teff) cells limited by the physical …

CD19-targeting chimeric antigen receptors (CARs) with CD28 and CD3ζ signaling domains
have been approved by the US FDA for treating B cell malignancies. Mutation of …

In cancer, persistent antigens drive CD8+ T cell differentiation into exhausted progenitor
(Texprog) and terminally exhausted (Texterm) cells. However, how the extrinsic and intrinsic …

Protein synthesis supports robust immune responses. Nutrient competition and global cell
stressors in the tumor microenvironment (TME) may impact protein translation in T cells and …

In recent years, various breakthroughs have been made in tumor immunotherapy that have
contributed to prolonging the survival of tumor patients. However, only a subset of patients …

Cytokines are known for their pleiotropic effects. They can be classified by their function as
pro-inflammatory, such as tumor necrosis factor (TNF), interleukin (IL) 1 and IL-12, or anti …

Hepatocellular carcinoma (HCC), one of the most common tumours worldwide, is one of the
main causes of mortality in cancer patients. There are still numerous problems hindering its …