Systemic sclerosis (scleroderma) is an autoimmune‐triggered chronic fibrosing disease that
affects the skin and many other organs. Its pathophysiology is complex and involves an early …

Cartilage oligomeric matrix protein (COMP) is a large pentameric glycoprotein that interacts
with multiple extracellular matrix proteins in cartilage and other tissues. While, COMP is …

Although osteoarthritis (OA) is the most common musculoskeletal condition that causes
significant health and social problems worldwide, its exact etiology is still unclear. With an …

Adhesions are fibrotic scars that form between abdominal organs following surgery or
infection, and may cause bowel obstruction, chronic pain, or infertility. Our understanding of …

Cartilage oligomeric matrix protein (COMP) is an extracellular matrix (ECM) glycoprotein that
is critical for collagen assembly and ECM stability. Mutations of COMP cause endoplasmic …

ABSTRACT TGFB1 (transforming growth factor beta 1) is a potent cytokine playing a driving
role in development, fibrosis and cancer. It is synthesized as prodomain-growth factor …

Rationale: Analyzing the molecular heterogeneity of different forms of organ fibrosis may
reveal common and specific factors and thus identify potential future therapeutic targets …

Fibrillar collagens of the extracellular matrix are critical for tissue structure and physiology;
however, excessive or abnormal deposition of collagens is a defining feature of fibrosis …

Background Chronic nodular prurigo (CNPG) is an inflammatory skin disease that is
maintained by a chronic itch-scratch cycle likely rooted in neuroimmunological …

Many different diseases are associated with fibrosis of the skin. The clinical symptoms can
vary considerably with a broad range from isolated small areas to the involvement of the …