Successfully translating anti-cancer nanomedicines from pre-clinical proof of concept to
demonstration of therapeutic value in the clinic is challenging. Having made significant …

Recent advances in controlled/living polymerization techniques and highly efficient coupling
chemistries have enabled the facile synthesis of complex polymer architectures with …

As the mainstay in the treatment of various cancers, chemotherapy plays a vital role, but still
faces many challenges, such as poor tumour selectivity and multidrug resistance (MDR) …

The enhanced permeability and retention (EPR) effect of solid tumors as seen with
nanomedicines and macromolecular drugs is well known. However, many researchers …

Over the past decade, star polymers have been widely used in biomedical applications such
as drug delivery, gene delivery, tissue engineering, diagnosis, medical devices, and …

Solid tumor has unique vascular architecture, excessive production of vascular mediators,
and extravasation of macromolecules from blood vessels into the tumor tissue interstitium …

Enhanced permeability and retention (EPR) and the (over-) expression of angiogenesis-
related surface receptors are key features of tumor blood vessels. As a consequence, EPR …

In the past several decades, nanosized drug delivery systems with various targeting
functions and controlled drug release capabilities inside targeted tissues or cells have been …

Recently, numerous polymer materials have been employed as drug carrier systems in
medicinal research, and their detailed properties have been thoroughly evaluated. Water …

Since the conceptualization of nanomedicine, numerous nanostructure‐mediated drug
formulations have progressed into clinical trials for treating cancer. However, recent clinical …