Overview of current drug delivery methods across the blood–brain barrier for the treatment of primary brain tumors

R Haumann, JC Videira, GJL Kaspers… - CNS drugs, 2020 - Springer
Existing drug delivery methods have not led to a significant increase in survival for patients
with malignant primary brain tumors. While the combination of conventional therapies …

The role of chromatin remodeler SMARCA4/BRG1 in brain cancers: a potential therapeutic target

SM Navickas, KA Giles, KH Brettingham-Moore… - Oncogene, 2023 - nature.com
The chromatin remodeler SMARCA4/BRG1 is a key epigenetic regulator with diverse roles
in coordinating the molecular programs that underlie brain tumour development. BRG1 …

Molecular engines, therapeutic targets, and challenges in pediatric brain tumors: a special emphasis on hydrogen sulfide and RNA-based nano-delivery

SA Fahmy, A Dawoud, YA Zeinelabdeen, CJ Kiriacos… - Cancers, 2022 - mdpi.com
Simple Summary Pediatric brain tumors represent a formidable challenge in the field of
oncology. Pediatric brain tumors are sub-classified into several molecular sub-types, where …

Residential exposure to pesticides as risk factor for childhood and young adult brain tumors: A systematic review and meta-analysis

G Van Maele-Fabry, L Gamet-Payrastre… - Environment international, 2017 - Elsevier
Background Accumulating evidence suggests a positive association between exposure to
non-agricultural pesticides and childhood brain tumors (CBT). Objective (1) To conduct a …

Advanced neuroimaging approaches to pediatric brain tumors

RM Nikam, X Yue, G Kaur, V Kandula, A Khair… - Cancers, 2022 - mdpi.com
Simple Summary After leukemias, brain tumors are the most common cancers in children,
and early, accurate diagnosis is critical to improve patient outcomes. Beyond the …

Biomarkers and corresponding biosensors for childhood cancer diagnostics

A Gharehzadehshirazi, M Zarejousheghani, S Falahi… - Sensors, 2023 - mdpi.com
Although tremendous progress has been made in treating childhood cancer, it is still one of
the leading causes of death in children worldwide. Because cancer symptoms overlap with …

CAR T-Cell therapy in children with solid tumors

M Kulczycka, K Derlatka, J Tasior, M Lejman… - Journal of Clinical …, 2023 - mdpi.com
The limited efficacy of traditional cancer treatments, including chemotherapy, radiotherapy,
and surgery, emphasize the significance of employing innovative methods. CAR (Chimeric …

In Vivo and Ex Vivo Pediatric Brain Tumor Models: An Overview

Z Li, SA Langhans - Frontiers in oncology, 2021 - frontiersin.org
After leukemia, tumors of the brain and spine are the second most common form of cancer in
children. Despite advances in treatment, brain tumors remain a leading cause of death in …

Potential biomarkers of childhood brain tumor identified by proteomics of cerebrospinal fluid from extraventricular drainage (EVD)

M Bruschi, A Petretto, A Cama, M Pavanello… - Scientific Reports, 2021 - nature.com
Brain tumors are the most common solid tumors in childhood. There is the need for
biomarkers of residual disease, therapy response and recurrence. Cerebrospinal fluid (CSF) …

Congenital tumors of the central nervous system: an institutional review of 64 cases with emphasis on tumors with unique histologic and molecular characteristics

AN Viaene, C Pu, A Perry, MM Li, M Luo… - Brain …, 2021 - Wiley Online Library
Congenital brain tumors are rare accounting for 0.5%–1.9% of all pediatric brain tumors.
While different criteria have been used to classify a tumor as congenital, those diagnosed …