Exploring phylogeny to find the function of sleep
During sleep, animals do not eat, reproduce or forage. Sleeping animals are vulnerable to
predation. Yet, the persistence of sleep despite evolutionary pressures, and the deleterious …
predation. Yet, the persistence of sleep despite evolutionary pressures, and the deleterious …
General principles of neuronal co-transmission: insights from multiple model systems
E Svensson, J Apergis-Schoute, G Burnstock… - Frontiers in neural …, 2019 - frontiersin.org
It is now accepted that neurons contain and release multiple transmitter substances.
However, we still have only limited insight into the regulation and functional effects of this co …
However, we still have only limited insight into the regulation and functional effects of this co …
The neuropeptidergic connectome of C. elegans
Efforts are ongoing to map synaptic wiring diagrams, or connectomes, to understand the
neural basis of brain function. However, chemical synapses represent only one type of …
neural basis of brain function. However, chemical synapses represent only one type of …
[HTML][HTML] System-wide mapping of peptide-GPCR interactions in C. elegans
I Beets, S Zels, E Vandewyer, J Demeulemeester… - Cell reports, 2023 - cell.com
Neuropeptides and peptide hormones are ancient, widespread signaling molecules that
underpin almost all brain functions. They constitute a broad ligand-receptor network, mainly …
underpin almost all brain functions. They constitute a broad ligand-receptor network, mainly …
Longitudinal imaging of Caenorhabditis elegans in a microfabricated device reveals variation in behavioral decline during aging
The roundworm C. elegans is a mainstay of aging research due to its short lifespan and
easily manipulable genetics. Current, widely used methods for long-term measurement of C …
easily manipulable genetics. Current, widely used methods for long-term measurement of C …
Whole-organism behavioral profiling reveals a role for dopamine in state-dependent motor program coupling in C. elegans
Animal behaviors are commonly organized into long-lasting states that coordinately impact
the generation of diverse motor outputs such as feeding, locomotion, and grooming …
the generation of diverse motor outputs such as feeding, locomotion, and grooming …
Dynamic functional connectivity in the static connectome of Caenorhabditis elegans
SW Flavell, A Gordus - Current opinion in neurobiology, 2022 - Elsevier
A hallmark of adaptive behavior is the ability to flexibly respond to sensory cues. To
understand how neural circuits implement this flexibility, it is critical to resolve how a static …
understand how neural circuits implement this flexibility, it is critical to resolve how a static …
Neuropeptide Y regulates sleep by modulating noradrenergic signaling
Sleep is an essential and evolutionarily conserved behavioral state whose regulation
remains poorly understood. To identify genes that regulate vertebrate sleep, we recently …
remains poorly understood. To identify genes that regulate vertebrate sleep, we recently …
Many faces of sleep regulation: beyond the time of day and prior wake time
The two‐process model of sleep regulation posits two main processes regulating sleep: the
circadian process controlled by the circadian clock and the homeostatic process that …
circadian process controlled by the circadian clock and the homeostatic process that …
Genetic and neuronal regulation of sleep by neuropeptide VF
Sleep is an essential and phylogenetically conserved behavioral state, but it remains
unclear to what extent genes identified in invertebrates also regulate vertebrate sleep …
unclear to what extent genes identified in invertebrates also regulate vertebrate sleep …