Proteasome inhibitor drugs
LD Fricker - Annual review of pharmacology and toxicology, 2020 - annualreviews.org
Proteasomes are large, multicatalytic protein complexes that cleave cellular proteins into
peptides. There are many distinct forms of proteasomes that differ in catalytically active …
peptides. There are many distinct forms of proteasomes that differ in catalytically active …
Human tear proteomics and peptidomics in ophthalmology: Toward the translation of proteomic biomarkers into clinical practice
Tears are a complex biological mixture containing electrolytes, metabolites, lipids, mucins,
some small organic molecules, and proteins. The tear film has various roles in the …
some small organic molecules, and proteins. The tear film has various roles in the …
Highly specific revelation of rat serum glycopeptidome by boronic acid-functionalized mesoporous silica
L Liu, Y Zhang, L Zhang, G Yan, J Yao, P Yang… - Analytica chimica …, 2012 - Elsevier
Although the specific profiling of endogenous glycopeptides in serum is highly inclined
towards the discovery of disease biomarkers, studies on the endogenous glycopeptides …
towards the discovery of disease biomarkers, studies on the endogenous glycopeptides …
Comparison of the MHC I immunopeptidome repertoire of B‐cell lymphoblasts using two isolation methods
J Lanoix, C Durette, M Courcelles, É Cossette… - …, 2018 - Wiley Online Library
Significant technological advances in both affinity chromatography and mass spectrometry
have facilitated the identification of peptides associated with the major histocompatibility …
have facilitated the identification of peptides associated with the major histocompatibility …
Sample preparation techniques for the untargeted LC‐MS‐based discovery of peptides in complex biological matrices
I Finoulst, M Pinkse, W Van Dongen… - BioMed Research …, 2011 - Wiley Online Library
Although big progress has been made in sample pretreatment over the last years, there are
still considerable limitations when it comes to overcoming complexity and dynamic range …
still considerable limitations when it comes to overcoming complexity and dynamic range …
Alterations of the intracellular peptidome in response to the proteasome inhibitor bortezomib
JS Gelman, J Sironi, I Berezniuk, S Dasgupta… - PloS one, 2013 - journals.plos.org
Bortezomib is an antitumor drug that competitively inhibits proteasome beta-1 and beta-5
subunits. While the impact of bortezomib on protein stability is known, the effect of this drug …
subunits. While the impact of bortezomib on protein stability is known, the effect of this drug …
Mechanistic peptidomics: factors that dictate specificity in the formation of endogenous peptides in human milk
A Guerrero, DC Dallas, S Contreras, S Chee… - Molecular & Cellular …, 2014 - ASBMB
An extensive mass spectrometry analysis of the human milk peptidome has revealed almost
700 endogenous peptides from 30 different proteins. Two in-house computational tools were …
700 endogenous peptides from 30 different proteins. Two in-house computational tools were …
Neuropeptides and other bioactive peptides: from discovery to function
LD Fricker - 2012 - books.google.com
Neuropeptides and peptide hormones represent the largest class of chemical messengers
that transmit information from one cell to another. In this review, several decades of research …
that transmit information from one cell to another. In this review, several decades of research …
Biological consequences of structural and functional proteasome diversity
AV Morozov, VL Karpov - Heliyon, 2018 - cell.com
Cell homeostasis and regulation of metabolic pathways are ensured by synthesis, proper
folding and efficient degradation of a vast amount of proteins. Ubiquitin-proteasome system …
folding and efficient degradation of a vast amount of proteins. Ubiquitin-proteasome system …
Intracellular peptides in cell biology and pharmacology
Intracellular peptides are produced by proteasomes following degradation of nuclear,
cytosolic, and mitochondrial proteins, and can be further processed by additional peptidases …
cytosolic, and mitochondrial proteins, and can be further processed by additional peptidases …