Proteasomes are large, multicatalytic protein complexes that cleave cellular proteins into
peptides. There are many distinct forms of proteasomes that differ in catalytically active …

Tears are a complex biological mixture containing electrolytes, metabolites, lipids, mucins,
some small organic molecules, and proteins. The tear film has various roles in the …

Although the specific profiling of endogenous glycopeptides in serum is highly inclined
towards the discovery of disease biomarkers, studies on the endogenous glycopeptides …

Significant technological advances in both affinity chromatography and mass spectrometry
have facilitated the identification of peptides associated with the major histocompatibility …

Although big progress has been made in sample pretreatment over the last years, there are
still considerable limitations when it comes to overcoming complexity and dynamic range …

Bortezomib is an antitumor drug that competitively inhibits proteasome beta-1 and beta-5
subunits. While the impact of bortezomib on protein stability is known, the effect of this drug …

An extensive mass spectrometry analysis of the human milk peptidome has revealed almost
700 endogenous peptides from 30 different proteins. Two in-house computational tools were …

Neuropeptides and peptide hormones represent the largest class of chemical messengers
that transmit information from one cell to another. In this review, several decades of research …

Cell homeostasis and regulation of metabolic pathways are ensured by synthesis, proper
folding and efficient degradation of a vast amount of proteins. Ubiquitin-proteasome system …

Intracellular peptides are produced by proteasomes following degradation of nuclear,
cytosolic, and mitochondrial proteins, and can be further processed by additional peptidases …