Heart failure with preserved ejection fraction in perspective

MA Pfeffer, AM Shah, BA Borlaug - Circulation research, 2019 - Am Heart Assoc
Approximately half of the patients with signs and symptoms of heart failure have a left
ventricular ejection fraction that is not markedly abnormal. Despite the historically initial …

The pathophysiology of heart failure with preserved ejection fraction

BA Borlaug - Nature Reviews Cardiology, 2014 - nature.com
Approximately half of all patients with heart failure have preserved ejection fraction (HFpEF)
and, as life expectancies continue to increase in western societies, the prevalence of HFpEF …

2016 focused update: clinical recommendations for cardiopulmonary exercise testing data assessment in specific patient populations

M Guazzi, R Arena, M Halle, MF Piepoli, J Myers… - Circulation, 2016 - Am Heart Assoc
In the past several decades, cardiopulmonary exercise testing (CPX) has seen an
exponential increase in its evidence base. The growing volume of evidence in support of …

Right heart dysfunction in heart failure with preserved ejection fraction

V Melenovsky, SJ Hwang, G Lin… - European heart …, 2014 - academic.oup.com
Aim Right heart function is not well characterized in patients with heart failure and preserved
ejection fraction (HFpEF). The goal of this study was to examine the haemodynamic, clinical …

Pulmonary hypertension in heart failure: pathophysiology, pathobiology, and emerging clinical perspectives

M Guazzi, R Naeije - Journal of the American College of Cardiology, 2017 - jacc.org
Pulmonary hypertension is a common hemodynamic complication of heart failure. Interest in
left-sided pulmonary hypertension has increased remarkably in recent years because its …

Pulmonary hypertension due to left heart diseases

JL Vachiéry, Y Adir, JA Barberà, H Champion… - Journal of the American …, 2013 - jacc.org
Pulmonary hypertension (PH), a common complication of left heart diseases (LHD),
negatively impacts symptoms, exercise capacity, and outcome. Although the true prevalence …

Left atrial remodeling and function in advanced heart failure with preserved or reduced ejection fraction

V Melenovsky, SJ Hwang, MM Redfield… - Circulation: Heart …, 2015 - Am Heart Assoc
Background—Left atrial (LA) structure and function are altered in most heart failure (HF)
patients, but there may be fundamental differences in LA properties between HF with …

Abnormal right ventricular-pulmonary artery coupling with exercise in heart failure with preserved ejection fraction

BA Borlaug, GC Kane, V Melenovsky… - European heart …, 2016 - academic.oup.com
Background Exercise intolerance is common in people with heart failure and preserved
ejection fraction (HFpEF). Right ventricular (RV) dysfunction has been shown at rest in …

Tricuspid annular plane systolic excursion and pulmonary arterial systolic pressure relationship in heart failure: an index of right ventricular contractile function and …

M Guazzi, F Bandera, G Pelissero… - American Journal …, 2013 - journals.physiology.org
Echo-derived pulmonary arterial systolic pressure (PASP) and right ventricular (RV) tricuspid
annular plane systolic excursion (TAPSE; from the end of diastole to end-systole) are of …

New strategies for heart failure with preserved ejection fraction: the importance of targeted therapies for heart failure phenotypes

M Senni, WJ Paulus, A Gavazzi, AG Fraser… - European heart …, 2014 - academic.oup.com
The management of heart failure with reduced ejection fraction (HF-REF) has improved
significantly over the last two decades. In contrast, little or no progress has been made in …