Ultraviolet radiation (UVR) has numerous effects on skin, including DNA damage, tanning,
vitamin D synthesis, carcinogenesis, and immunomodulation. Keratinocytes containing …

Different skin colour among individuals is determined by the varying amount and types of
melanin pigment. Melanin is produced in melanocytes, a type of dendritic cell located in the …

This volume covers all aspects of melanin pigmentation, providing a concise,
comprehensive picture of new knowledge gained at the frontiers of research. It draws …

Some twenty years have passed since Swan reviewed the chemistry of melanins for Vol. 31
of this series (1). Although some of the questions which he aired at that time have remained …

Glutathione is an ubiquitous compound found in our bodies. Aside from its many ascribed
biologic functions, it has also been implicated in skin lightening. We review in vitro and in …

Melanocytic cells can produce two types of pigment, pheomelanin or eumelanin. We used
two types of human melanoma cell lines to explore the regulation of pigmentation by …

The last decade has witnessed a quantum jump in our knowledge of the chemistry of
melanogenesis and the emergence of some understanding as to how the chemical and …

The aim of the present work was to estimate the effect of intracellular glutathione depletion
on melanogenesis in human melanoma cells. We determined tyrosine hydroxylation activity …

An analytical quantitative high‐pressure liquid chromatography (HPLC) method was
developed for simultaneous determination of all mercaptobeazothiazole derivatives in the …

Cutaneous melanoma (CM) is the most aggressive skin cancer, showing globally increasing
incidence. Hereditary CM accounts for a significant percentage (5–15%) of all CM cases …