Wound healing (WH) and the role fibroblasts play in the process, as well as healing
impairment and fibroblast dysfunction, have been thoroughly reviewed by other authors. We …

Platelets are small anucleated blood cells primarily known for their vital hemostatic role.
Allogeneic platelet concentrates (PCs) collected from healthy donors are an essential …

The management of diabetic wounds remains a critical therapeutic challenge. Platelet-rich
plasma (PRP) gel, PRP-derived exosomes (PRP-Exos), and mesenchymal stem cell-derived …

Abstract Background Sphingosine-1-phosphate (S1P), a key regulator of vascular
homeostasis and angiogenesis, is enriched in exosomes derived from platelet-rich plasma …

The preparation of autologous platelet and extracellular vesicle-rich plasma (PVRP) has
been explored in many medical fields with the aim to benefit from its healing potential. In …

Objective This paper reviews the research of platelet-rich plasma (PRP) in articular cartilage
injury repair, to assess the mechanism, utilization, and efficacy of PRP in the treatment of …

The frequency of chronic cutaneous wounds are sharply increasing in aging populations.
Patients with age-related diseases, such as diabetes, tumors, renal failure and stroke are …

Platelets are a reservoir of growth factors, cytokines and chemokines involved in
spontaneous wound repair. In this study, a platelet-rich and fibrin-rich hydrogel was …

Wound healing is a complex and iterative process involving myriad cellular and biologic
processes that are highly regulated to allow satisfactory repair and regeneration of damaged …

Damaged cartilage is seen with increasing frequency after joint trauma, alone or in
combination with other joint injuries. A poor healing of injured cartilage leads to great …