The association between inflammation, infection, and venous thrombosis has long been
recognized; yet, only in the last decades have we begun to understand the mechanisms …

In addition to physical barriers, neutrophils are considered a part of the first line of immune
defense. They can be found in the bloodstream, with a lifespan of 6–8 h, and in tissue …

NETosis is a regulated form of neutrophil cell death that contributes to the host defense
against pathogens and was linked to various diseases soon after its first description in 2004 …

Neutrophil extracellular traps expelled from suicidal neutrophils comprise a complex
structure of nuclear chromatin and proteins of nuclear, granular, and cytosolic origin. These …

Uncontrolled haemorrhage is a major preventable cause of death in patients with traumatic
injury. Trauma-induced coagulopathy (TIC) describes abnormal coagulation processes that …

Alarmins are preformed, endogenous molecules that can be promptly released to signal cell
or tissue stress or damage. The ubiquitous nuclear molecule high-mobility group box 1 …

Thrombotic complications are still a major health risk worldwide. Our view on the
pathophysiology of thrombosis has significantly changed since the discovery of neutrophil …

Introduction: High-mobility group box 1 (HMGB1) is a ubiquitous nuclear protein that
promotes inflammation when released extracellularly after cellular activation, stress …

A single protein, HMGB 1, directs the triggering of inflammation, innate and adaptive
immune responses, and tissue healing after damage. HMGB 1 is the best characterized …

COVID-19 patients have a high incidence of thrombosis, and thromboembolic complications
are associated with severe COVID-19 and high mortality. COVID-19 disease is associated …