[HTML][HTML] Antibody-associated epilepsies: clinical features, evidence for immunotherapies and future research questions
Purpose The growing recognition of epilepsies and encephalopathies associated with
autoantibodies against surface neuronal proteins (LGI1, NMDAR, CASPR2, GABA BR, and …
autoantibodies against surface neuronal proteins (LGI1, NMDAR, CASPR2, GABA BR, and …
Inhibitory axons are targeted in hippocampal cell culture by anti-Caspr2 autoantibodies associated with limbic encephalitis
D Pinatel, B Hivert, J Boucraut… - Frontiers in Cellular …, 2015 - frontiersin.org
Contactin-associated protein-like 2 (Caspr2), also known as CNTNAP2, is a cell adhesion
molecule that clusters voltage-gated potassium channels (Kv1. 1/1.2) at the juxtaparanodes …
molecule that clusters voltage-gated potassium channels (Kv1. 1/1.2) at the juxtaparanodes …
Autoantibodies to neuronal antigens in children with new‐onset seizures classified according to the revised ILAE organization of seizures and epilepsies
Purpose Potentially pathogenic autoantibodies are found increasingly in adults with seizure
disorders, including focal seizures and those of unknown cause. In this study, we …
disorders, including focal seizures and those of unknown cause. In this study, we …
IgG leakage may contribute to neuronal dysfunction in drug-refractory epilepsies with blood-brain barrier disruption
Z Michalak, A Lebrun, MD Miceli… - … of Neuropathology & …, 2012 - academic.oup.com
Focal epilepsies are often associated with blood-brain barrier disruption. In 4 entorhinal
cortex tissue samples and 13 hippocampal samples from patients with pharmacoresistent …
cortex tissue samples and 13 hippocampal samples from patients with pharmacoresistent …
Autoimmune epilepsy
Despite the fact that epilepsy is the third most common chronic brain disorder, relatively little
is known about the processes leading to the generation of seizures. Accumulating data …
is known about the processes leading to the generation of seizures. Accumulating data …
ADAM22 and ADAM23 modulate the targeting of the Kv1 channel-associated protein LGI1 to the axon initial segment
B Hivert, L Marien, KN Agbam… - Journal of Cell …, 2019 - journals.biologists.com
The distribution of the voltage-gated Kv1 K+ channels at the axon initial segment (AIS)
influences neuronal intrinsic excitability. The Kv1. 1 and Kv1. 2 (also known as KCNA1 and …
influences neuronal intrinsic excitability. The Kv1. 1 and Kv1. 2 (also known as KCNA1 and …
The challenges and innovations for therapy in children with epilepsy
Major advances have been made in the diagnosis, evaluation and management of children
with epilepsy over the past 15 years. There has been a marked increase in genetic …
with epilepsy over the past 15 years. There has been a marked increase in genetic …
[HTML][HTML] Autoimmune encephalitis—new awareness, challenging questions
The field of autoimmune encephalopathies has expanded rapidly in the last few years. It is
now well-established that a substantial proportion of encephalitides are associated with …
now well-established that a substantial proportion of encephalitides are associated with …
Drebrin autoantibodies in patients with seizures and suspected encephalitis
J Pitsch, D Kamalizade, A Braun, JC Kuehn… - Annals of …, 2020 - Wiley Online Library
Objective Assess occurrence of the dendritic spine scaffolding protein Drebrin as a
pathophysiologically relevant autoantibody target in patients with recurrent seizures and …
pathophysiologically relevant autoantibody target in patients with recurrent seizures and …
Encephalitis with antibodies against the GABAB receptor: seizures as the most common presentation at admission
X Chen, F Liu, JM Li, X Xie, Q Wang, D Zhou… - Neurological …, 2017 - Taylor & Francis
Objective: Autoimmune encephalitis associated with antibodies against gamma-
aminobutyric-acid B receptor (GABABR) has not been described in detail in Chinese …
aminobutyric-acid B receptor (GABABR) has not been described in detail in Chinese …