Voltage-gated potassium channel–complex autoimmunity and associated clinical syndromes

SR Irani, A Vincent - Handbook of Clinical Neurology, 2016 - Elsevier
Voltage-gated potassium channel (VGKC)–complex antibodies are defined by the
radioimmunoprecipitation of Kv1 potassium channel subunits from brain tissue extracts and …

New insights into the roles of the contactin cell adhesion molecules in neural development

AN Mohebiany, S Harroch, S Bouyain - Cell Adhesion Molecules …, 2014 - Springer
In vertebrates, the contactin (CNTN) family of neural cell recognition molecules includes six
related cell adhesion molecules that play non-overlapping roles in the formation and …

Mesial temporal lobe epilepsy with hippocampal sclerosis is infrequently associated with neuronal autoantibodies

AW Nóbrega‐Jr, CP Gregory, R Schlindwein‐Zanini… - …, 2018 - Wiley Online Library
Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE‐HS) is characterized by its
well‐defined clinical profile. Limbic encephalitis is increasingly recognized as a possible …

Value of autoantibodies for prediction of treatment response in patients with autoimmune epilepsy: review of the literature and suggestions for clinical management

CG Bien - Epilepsia, 2013 - Wiley Online Library
The detection of antineural autoantibodies in patients with epilepsy has led to the new
concept of “autoimmune epilepsy.” A particularly important implication is that knowledge of …

Modulation of immunity and the inflammatory response: a new target for treating drug-resistant epilepsy

N Yu, H Liu, Q Di - Current Neuropharmacology, 2013 - ingentaconnect.com
Until recently, epilepsy medical therapy is usually limited to anti-epileptic drugs (AEDs).
However, approximately 1/3 of epilepsy patients, described as drug-resistant epilepsy (DRE) …

[HTML][HTML] Retrospective case series of the clinical features, management and outcomes of patients with autoimmune epilepsy

D Dubey, N Samudra, P Gupta, M Agostini, K Ding… - Seizure, 2015 - Elsevier
Purpose Analyze clinical and electrographic characteristics of patients with autoimmune
epilepsy, and evaluate the effect of early diagnosis and treatment on reduction of seizure …

Psychiatric phenomena as initial manifestation of encephalitis by anti‐NMDAR antibodies

P Maat, E de Graaff, NM van Beveren… - Acta …, 2013 - cambridge.org
ObjectiveAutoimmune encephalitis associated with autoantibodies against the N‐methyl‐d‐
aspartate receptor (NMDAR) often presents with behavioural change. Our objective was to …

[HTML][HTML] Selective limbic blood–brain barrier breakdown in a feline model of limbic encephalitis with LGI1 antibodies

AR Tröscher, A Klang, M French… - Frontiers in …, 2017 - frontiersin.org
Human leucine-rich glioma-inactivated protein 1 encephalitis (LGI1) is an autoimmune
limbic encephalitis in which serum and cerebrospinal fluid contain antibodies targeting LGI1 …

Immunomodulatory treatments in epilepsy

JJ Melvin, HH Hardison - Seminars in pediatric neurology, 2014 - Elsevier
The role of immunity and inflammation appears to be an integral part of the pathogenic
processes associated with some seizures, particularly with refractory epilepsy. Prompt …

[HTML][HTML] Assembly and function of the juxtaparanodal Kv1 complex in health and disease

D Pinatel, C Faivre-Sarrailh - Life, 2020 - mdpi.com
The precise axonal distribution of specific potassium channels is known to secure the shape
and frequency of action potentials in myelinated fibers. The low-threshold voltage-gated Kv1 …