The new WHO classification of adrenal cortical proliferations reflects translational advances
in the fields of endocrine pathology, oncology and molecular biology. By adopting a …

Closely associated with aging and age-related disorders, cellular senescence (CS) is the
inability of cells to proliferate due to accumulated unrepaired cellular damage and …

As a major neuron type in the brain, the excitatory neuron (EN) regulates the lifespan in C.
elegans. How the EN acquires senescence, however, is unknown. Here, we show that …

Cellular senescence is implicated in a wide range of physiological and pathological
conditions throughout an organism's entire lifetime. In particular, it has become evident that …

The contribution of cellular senescence to a diverse range of biological processes, including
normal physiology, ageing, and pathology were long overlooked but have now taken centre …

Cellular senescence is an irreversible state of cell cycle arrest, characterized by a gradual
decline in cell proliferation, differentiation, and biological functions. Cellular senescence is …

Endothelial cells are constantly exposed to environmental stress factors that, above a certain
threshold, trigger cellular senescence and apoptosis. The altered vascular function affects …

Cellular senescence is a state of permanent growth arrest. It can be triggered by telomere
shortening (replicative senescence) or prematurely induced by stresses such as DNA …

Senescence is a cellular stress response that involves prolonged cell survival, a quasi-
irreversible proliferative arrest and a modification of the transcriptome that sometimes …

Background Premature ovarian insufficiency (POI) is one of the common women
reproductive endocrine diseases which adversely impacts female fertility, but the etiology …