Obesity, a worldwide epidemic, confers increased risk for multiple serious conditions,
including type 2 diabetes, cardiovascular diseases, nonalcoholic fatty liver disease and …

The global obesity epidemic is a major contributor to chronic disease and disability in the
world today. Since the discovery of leptin in 1994, a multitude of studies have characterized …

Dysregulated inflammation is a central pathological process in diverse disease states.
Traditionally, therapeutic approaches have sought to modulate the pro-or anti-inflammatory …

During the last 40 years, there has been a world-wide increase in both the prevalence of
obesity and an increase in the number of persons over the age of 60 due to a decline in …

For many years, adipose tissue was considered as an inert energy storage organ that
accumulates and stores triacylglycerols during energy excess and releases fatty acids in …

The chemokine superfamily consists of a large number of ligands and receptors. At first
glance, this family appears redundant and their ligand-receptor relationships promiscuous …

Simple Summary Non-alcoholic fatty liver disease (NAFLD) is an unmet medical need due to
its increasingly high incidence, severe clinical consequences, and the absence of feasible …

Chemokines have fundamental roles in regulating immune and inflammatory responses,
primarily through their control of leukocyte migration and localization. The biological …

The discovery of adipokines has revealed adipose tissue as a central node in the interorgan
crosstalk network, which mediates the regulation of multiple organs and tissues. Adipose …

In 2005, the International Union of Basic and Clinical Pharmacology Committee on Receptor
Nomenclature and Drug Classification (NC-IUPHAR) published a catalog of all of the human …