Inhaled corticosteroids for stable chronic obstructive pulmonary disease

IA Yang, MS Clarke, EHA Sim… - Cochrane Database of …, 2012 - cochranelibrary.com
Background The role of inhaled corticosteroids (ICS) in chronic obstructive pulmonary
disease (COPD) has been the subject of much controversy. Major international guidelines …

Canadian Thoracic Society recommendations for management of chronic obstructive pulmonary disease–2007 update

DE O'donnell, S Aaron, J Bourbeau… - Canadian …, 2007 - Wiley Online Library
Chronic obstructive pulmonary disease (COPD) is a major respiratory illness in Canada that
is both preventable and treatable. Our understanding of the pathophysiology of this complex …

Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease

PMA Calverley, JA Anderson, B Celli… - … England Journal of …, 2007 - Mass Medical Soc
Background Long-acting beta-agonists and inhaled corticosteroids are used to treat chronic
obstructive pulmonary disease (COPD), but their effect on survival is unknown. Methods We …

Tiotropium in combination with placebo, salmeterol, or fluticasone–salmeterol for treatment of chronic obstructive pulmonary disease: a randomized trial

SD Aaron, KL Vandemheen, D Fergusson… - Annals of internal …, 2007 - acpjournals.org
Background: Treatment of moderate or severe chronic obstructive pulmonary disease
(COPD) with combinations of inhaled corticosteroids, long-acting β-agonists, and long …

COPD as a lung disease with systemic consequences–clinical impact, mechanisms, and potential for early intervention

M Decramer, S Rennard, T Troosters… - COPD: Journal of …, 2008 - Taylor & Francis
The natural course of chronic obstructive pulmonary disease (COPD) is complicated by the
development of systemic consequences and co-morbidities. These may be major features in …

Inhaled corticosteroid use in chronic obstructive pulmonary disease and the risk of hospitalization for pneumonia

P Ernst, AV Gonzalez, P Brassard… - American journal of …, 2007 - atsjournals.org
Rationale: Inhaled corticosteroids are commonly prescribed to patients with chronic
obstructive pulmonary disease (COPD). Objectives: To examine whether these medications …

Corticosteroid resistance in chronic obstructive pulmonary disease: inactivation of histone deacetylase

PJ Barnes, K Ito, IM Adcock - The Lancet, 2004 - thelancet.com
By contrast with patients with asthma, those with chronic obstructive pulmonary disease
(COPD) are poorly responsive to the anti-inflammatory actions of corticosteroids, and these …

Inhaled corticosteroids in COPD: the clinical evidence

P Ernst, N Saad, S Suissa - European Respiratory Journal, 2015 - Eur Respiratory Soc
In this article, we focus on the scientific evidence from randomised trials supporting
treatment with inhaled corticosteroids (ICS) in chronic obstructive pulmonary disease …

A multidimensional grading system (BODE index) as predictor of hospitalization for COPD

KC Ong, A Earnest, SJ Lu - Chest, 2005 - Elsevier
Study objectives: We hypothesized that the BODE (body mass index, airflow obstruction,
dyspnea, and exercise capacity) index would better predict hospitalization for COPD than …

Corticosteroids: the drugs to beat

PJ Barnes - European journal of pharmacology, 2006 - Elsevier
Corticosteroids are the most effective anti-inflammatory therapy for asthma and other chronic
inflammatory and immune diseases. Recently new insights have been gained into the …