The cannabis derivative marijuana is the most widely used recreational drug in the Western
world and is consumed by an estimated 83 million individuals (∼ 3% of the world …

Summary Δ 9-tetrahydrocannabinol (THC) and its sibling, cannabidiol (CBD), are produced
by the same Cannabis plant and have similar chemical structures but differ dramatically in …

We report studies pertaining to two isomeric hexahydrocannabinols (HHCs),(9R)-HHC and
(9S)-HHC, which are derivatives of the psychoactive cannabinoids Δ9-and Δ8-THC. HHCs …

The management of visceral pain in patients with disorders of gut–brain interaction, notably
irritable bowel syndrome, presents a considerable clinical challenge, with few available …

Newborn neurons in the adult hippocampus are regulated by many intrinsic and extrinsic
cues. It is well accepted that elevated glucocorticoid levels lead to downregulation of adult …

The maintenance of intestinal homeostasis is fundamentally important to health. Intestinal
barrier function and immune regulation are key determinants of intestinal homeostasis and …

Cannabis is well established to impact affective states, emotion and perceptual processing,
primarily through its interactions with the endocannabinoid system. While cannabis use is …

Dentate gyrus of the hippocampus continuously gives rise to new neurons, namely, adult-
born granule cells, which contribute to conferring plasticity to the mature brain throughout …

The endocannabinoid system (ECS) is a lipid cell signaling system involved in the
physiology and homeostasis of the brain and peripheral tissues. Synaptic plasticity …

The discovery of cannabinoid receptors as the primary molecular targets of psychotropic
cannabinoid Δ9‐tetrahydrocannabinol (Δ9‐THC) in late 1980s paved the way for …