Melanoma is considered a multifactorial disease etiologically divided into melanomas
related to sun exposure and those that are not, but also based on their mutational …

Novel antibiotics are in constant demand to combat a global increase in antibiotic-resistant
infections. Bacterial natural products have been a long-standing source of antibiotic …

Streptomycetes have been, for over 70 years, one of the most abundant sources for the
discovery of new antibiotics and clinic drugs. However, in recent decades, it has been more …

Terpene cyclization, one of the most complex chemical reactions in nature, is generally
catalyzed by two classes of terpene cyclases (TCs). Cytochrome P450s that act as …

Deserts are extremely arid environments where life is exposed to multiple environmental
stresses, including low water availability, high temperatures, intense radiation environments …

Introduction Filamentous actinomycetes, notably members of the genus Streptomyces,
remain a rich source of new specialized metabolites, especially antibiotics. In addition, they …

Microorganisms are an important component of global biodiversity. However, they are
vulnerable to hyper-arid climates in desert regions. Xerophytes are desert vegetation with …

Fifteen polyketides, including four new compounds, isoversiol F (1), decumbenone D (2),
palitantin B (7), and 1, 3-di-O-methyl-norsolorinic acid (8), along with 11 known compounds …

A huge number of nitrogen-containing heterocyclic compounds are ubiquitous in natural
products, pharmaceuticals, and bioactive molecules. Among these, the pyranoindole …

Bacterial secondary metabolites represent an invaluable source of bioactive molecules for
the pharmaceutical and agrochemical industries. Although screening campaigns for the …