Therapeutic drug monitoring (TDM) is the quantification and interpretation of drug
concentrations in blood to optimize pharmacotherapy. It considers the interindividual …

Therapeutic drug monitoring (TDM), ie, the quantification of serum or plasma concentrations
of medications for dose optimization, has proven a valuable tool for the patient-matched …

BACKGROUND: Elderly patients are vulnerable to drug interactions because of age-related
physiologic changes, an increased risk for disease associated with aging, and the …

Lithium is an effective treatment in pregnancy and postpartum for the prevention of relapse
in bipolar disorder. However, lithium has also been associated with risks during pregnancy …

Lithium has been used clinically to treat bipolar disorder for over half a century, and remains
a fundamental pharmacological therapy for patients with this illness. Although lithium's …

Introduction: Despite more that 60 years of clinical experience, the effective use of lithium for
the treatment of mood disorder, in particular bipolarity, is in danger of becoming obsolete. In …

Lithium use in mental diseases has changed over the years but remains a cornerstone of
treatment in bipolar disorders. In two companion papers, we have reviewed existing (and …

Down syndrome (DS) patients exhibit abnormalities of hippocampal-dependent explicit
memory, a feature that is replicated in relevant mouse models of the disease. Adult …

Objective Pharmacotherapy for mood disorders during pregnancy is often complicated by
pregnancy-related pharmacokinetic changes and the need for dose adjustments. The …

The high rate of non-responders to initial treatment with antidepressants requires
subsequent treatment strategies such as augmentation of antidepressants. Clinical …