Relationships among smoking, oxidative stress, inflammation, macromolecular damage, and cancer

AW Caliri, S Tommasi, A Besaratinia - Mutation Research/Reviews in …, 2021 - Elsevier
Smoking is a major risk factor for a variety of diseases, including cancer and immune-
mediated inflammatory diseases. Tobacco smoke contains a mixture of chemicals, including …

Targeting aging pathways in chronic obstructive pulmonary disease

M Easter, S Bollenbecker, JW Barnes… - International journal of …, 2020 - mdpi.com
Chronic obstructive pulmonary disease (COPD) has become a global epidemic and is the
third leading cause of death worldwide. COPD is characterized by chronic airway …

Myricetin inhibits TNF-α-induced inflammation in A549 cells via the SIRT1/NF-κB pathway

M Chen, Z Chen, D Huang, C Sun, J Xie, T Chen… - Pulmonary …, 2020 - Elsevier
Background Although myricetin exerts anti-inflammation, anti-cancer, and anti-oxidation
effects, the relationship between myricetin and tumor necrosis factor alpha (TNF-α) …

Progression of cystic fibrosis lung disease from childhood to adulthood: neutrophils, neutrophil extracellular trap (NET) formation, and NET degradation

MA Khan, ZS Ali, N Sweezey, H Grasemann… - Genes, 2019 - mdpi.com
Genetic defects in cystic fibrosis (CF) transmembrane conductance regulator (CFTR) gene
cause CF. Infants with CFTR mutations show a peribronchial neutrophil infiltration prior to …

Osteoarthritis and toll-like receptors: when innate immunity meets chondrocyte apoptosis

G Barreto, M Manninen, K K. Eklund - Biology, 2020 - mdpi.com
Osteoarthritis (OA) has long been viewed as a degenerative disease of cartilage, but
accumulating evidence indicates that inflammation has a critical role in its pathogenesis. In …

Chlorinated organophosphate flame retardants impair the lung function via the IL-6/JAK/STAT signaling pathway

H Zhu, H Zhang, K Lu, S Yang, X Tang… - Environmental …, 2022 - ACS Publications
Toxicological studies have revealed the adverse impacts of organophosphate flame
retardants (OPFRs) on the respiratory system, while there is a lack of epidemiological …

Relationship of Serum Levels of IL‐17, IL‐18, TNF‐α, and Lung Function Parameters in Patients with COPD, Asthma‐COPD Overlap, and Bronchial Asthma

N Kubysheva, M Boldina, T Eliseeva… - Mediators of …, 2020 - Wiley Online Library
Determination of markers of systemic inflammation is one of the important directions in the
study of pathogenesis and improvement of diagnosis of chronic obstructive pulmonary …

[HTML][HTML] IL-33 blockade affects mediators of persistence and exacerbation in a model of chronic airway inflammation

J Allinne, G Scott, WK Lim, D Birchard… - Journal of Allergy and …, 2019 - Elsevier
Background Severe inflammatory airway diseases are associated with inflammation that
does not resolve, leading to structural changes and an overall environment primed for …

Nanotechnology based advanced therapeutic strategies for targeting interleukins in chronic respiratory diseases

MS Hussain, P Sharma, DS Dhanjal, N Khurana… - Chemico-biological …, 2021 - Elsevier
Both communicable and non-communicable chronic respiratory conditions have accorded
for suffering of millions of people of all ages and stated to be leading cause of death …

Isorhamnetin attenuates TNF‐α‐induced inflammation, proliferation, and migration in human bronchial epithelial cells via MAPK and NF‐κB pathways

X Ren, L Han, Y Li, H Zhao, Z Zhang… - The Anatomical …, 2021 - Wiley Online Library
Isorhamnetin has distinct anti‐inflammatory activity and inhibits cell proliferation and
migration. These effects are also involved in the pathogenesis of asthma. However, the …