Quinoline is one of the most important and versatile nitrogen heterocycles embodied in
several biologically active molecules. Within the numerous quinolines developed as …

Transition-metal-free direct arylation of CH or NH bonds is one of the key emerging
methodologies that is currently attracting tremendous attention. Diaryliodonium salts serve …

In this work, three new quinolone derivatives were prepared by alkylation of 2-oxo-1, 2-
dihydroquinoline-4-carboxylic acid with ethyl 2-bromoacetate. The synthesized compounds …

Synthesis of some novel Clioquinol linked annulated 1, 2, 3-triazole hybrids (4a-4n) via step-
economical copper-catalyzed cascade reactions was developed. It involves copper (I) …

Cancer is one of the most feared and dreaded diseases across the world. In clinical practice,
a variety of anticancer agents of natural, semi-synthetic and synthetic origin exist, but they …

Quinoline and quinazoline alkaloids, two important classes of N-based heterocyclic
compounds, have attracted scientific and popular interest worldwide since the 19th century …

Introduction The quinolone scaffold is a bicyclic benzene-pyridinic ring scaffold with nitrogen
at the first position and a carbonyl group at the second or fourth position. It is endowed with a …

Novel styryl-heterocyclic hybrids were designed and synthesized via Knoevenagel
condensation reaction between 4-(4-((5-(((4-methyl-2-oxo-2H-chromen-7-yl) oxy) methyl)-1 …

RM-581 is an aminosteroid derivative comprised of a steroid core and a quinoline side chain
showing potent cytotoxic activity on several types of cancer cells but for which the …

One of the leading causes of death worldwide is cancer, which poses substantial risks to
both society and an individual's life. Cancer therapy is still challenging, despite …