Induced tolerogenic dendritic cells are a powerful immunotherapy for autoimmune disease
that have shown promise in laboratory models of disease and early clinical trials. In contrast …

Inflammation-associated diseases encompass a range of infectious diseases and non-
infectious inflammatory diseases, which continuously pose one of the most serious threats to …

Background & aims In celiac disease (CeD), gluten induces immune activation, leading to
enteropathy. TAK-101, gluten protein (gliadin) encapsulated in negatively charged poly (dl …

Background & Aims Celiac disease could be treated, and potentially cured, by restoring T-
cell tolerance to gliadin. We investigated the safety and efficacy of negatively charged 500 …

Antigen-specific immune tolerance has been a long-standing goal for immunotherapy for the
treatment of autoimmune diseases and allergies and for the prevention of allograft rejection …

Effective intervention is essential to combat the coming epidemic of neurodegenerative (ND)
diseases. Nanomedicine can overcome restrictions of CNS delivery imposed by the blood …

Poly (lactic-co-glycolic acid)(PLGA) particles are a widely used and extensively studied drug
delivery system. The favorable properties of PLGA such as good bioavailability, controlled …

Tolerogenic vaccines are aimed at inhibiting antigen-specific immune responses. Antigen-
loaded nanoparticles (NPs) have been recently emerged as ideal tools for tolerogenic …

Traumatic primary spinal cord injury (SCI) results in paralysis below the level of injury and is
associated with infiltration of hematogenous innate immune cells into the injured cord …

It is difficult to carry out early diagnosis and treatment of Multiple sclerosis (MS) because of
the complex pathogenesis elicited by diversified autoantigens. Monocytes play important …