The electromechanical function of the heart involves complex, coordinated activity over time
and space. Life-threatening cardiac arrhythmias arise from asynchrony in these space–time …

Optogenetics is an elegant approach of precisely controlling and monitoring the biological
functions of a cell, group of cells, tissues, or organs with high temporal and spatial resolution …

The autonomic nervous system (ANS) with its two limbs, the sympathetic (SNS) and
parasympathetic nervous system (PSNS), plays a critical role in the modulation of cardiac …

The improvement of preclinical cardiotoxicity testing, discovery of new ion-channel-targeted
drugs, and phenotyping and use of stem cell-derived cardiomyocytes and other biologics all …

In nature, macroscopic excitation waves, are found in a diverse range of settings including
chemical reactions, metal rust, yeast, amoeba and the heart and brain. In the case of living …

Extracellular matrix (ECM) structure and biochemistry provide cell-instructive cues that
promote and regulate tissue growth, function, and repair. From a structural perspective, the …

Optogenetic techniques permit studies of excitable tissue through genetically expressed
light-gated microbial channels or pumps permitting transmembrane ion movement. Light …

The nervous system and cardiovascular system develop in concert and are functionally
interconnected in both health and disease. This white paper focuses on the cellular and …

Zebrafish are a relevant and useful vertebrate model species to study normal-and patho-
physiology, including that of the heart, due to conservation of protein-coding genes, organ …

Optogenetics is an exciting new technology that allows targetable fast control and readout of
specific neural populations in complex brain circuits. With the rapid development of light …