It has long been appreciated that the Gram-negative outer membrane acts as a permeability
barrier, but recent studies have uncovered a more expansive and versatile role for the outer …

Bacteria surround their cell membrane with a net-like peptidoglycan layer, called sacculus,
to protect the cell from bursting and maintain its cell shape. Sacculus growth during …

Most bacteria are surrounded by a peptidoglycan cell wall that defines their shape and
protects them from osmotic lysis. The expansion and division of this structure therefore plays …

Retrons are prokaryotic genetic retroelements encoding a reverse transcriptase that
produces multi-copy single-stranded DNA (msDNA). Despite decades of research on the …

Microbial genome sequencing projects produce numerous sequences of deduced proteins,
only a small fraction of which have been or will ever be studied experimentally. This leaves …

Linkages between the outer membrane of Gram-negative bacteria and the peptidoglycan
layer are crucial for the maintenance of cellular integrity and enable survival in challenging …

How bacteria grow and divide while retaining a defined shape is a fundamental question in
microbiology, but technological advances are now driving a new understanding of how the …

The bacterial division apparatus catalyses the synthesis and remodelling of septal
peptidoglycan (sPG) to build the cell wall layer that fortifies the daughter cell poles …

The peptidoglycan (PG) cell wall is an extra-cytoplasmic glycopeptide polymeric structure
that protects bacteria from osmotic lysis and determines cellular shape. Since the cell wall …

Covering 2000 to June 2015 This review discusses the biosynthesis of natural products that
are generated by trans-AT polyketide synthases, a family of catalytically versatile enzymes …