Although uncontrolled proliferation is a distinguishing property of a tumor as a whole, the
individual cells that make up the tumor exhibit considerable variation in many properties …

The culmination of decades of research on humanized mice is leading to advances in our
understanding of human haematopoiesis, innate and adaptive immunity, autoimmunity …

Abstract ß-thalassemia is caused by ß-globin gene mutations resulting in reduced (β+) or
absent (β0) hemoglobin production. Patient life expectancy has recently increased, but the …

Migration of hematopoietic stem cells through the blood, across the endothelial vasculature
to different organs and to their bone marrow (BM) niches, requires active navigation, a …

Abstract SDF-1α/CXCR4 signaling plays a key role in leukemia/bone marrow
microenvironment interactions. We previously reported that bone marrow–derived stromal …

Leukemia-initiating cells (LICs) in acute myeloid leukemia (AML) are believed to be
restricted to the CD34+ fraction. However, one of the most frequently mutated genes in AML …

Aldehyde dehydrogenase (ALDH) is an enzyme that is expressed in the liver and is required
for the conversion of retinol (vitamin A) to retinoic acids. ALDH is also highly enriched in …

Extracellular vesicles (EVs) including exosomes act as intercellular communicators by
transferring protein and microRNA cargoes, yet the role of EV lipids remains unclear. Here …

The nonobese diabetic/severe combined immune deficiency (NOD-scid)
xenotransplantation model is the “gold standard” for assaying human hematopoietic stem …

Hematopoietic stem cell homing and engraftment are crucial to transplantation efficiency,
and clinical engraftment is severely compromised when donor-cell numbers are limiting. The …