Many human tumor-associated antigens (TAAs) have recently been identified and
molecularly characterized. When bound to major histocompatibility complex molecules, TAA …

T-cell alloreactivity is a well-established phenomenon, but its molecular basis has remained
enigmatic. Although there are differences between T-cell recognition of conventional and …

Interactions of T cell antigen receptors (TCRs) with complexes of self peptide and major
histocompatibility complex (MHC) are crucial to T cell development, but their role in …

T cell receptor (TCR) cross-reactivity between major histocompatibility complex II (MHCII)-
binding self and foreign peptides could influence the naive CD4+ T cell repertoire and …

Escape from adaptive T cell immunity through transmutation of viral antigenic structure is a
cardinal feature in the pathogenesis of SIV/HIV infection and a major obstacle to …

A peptide derived from the insulin B chain contains a major epitope for diabetogenic CD4+ T
cells in the NOD mouse model of type 1 diabetes (T1D). This peptide can fill the binding …

T cell receptor (TCR) binding degeneracy lies at the heart of several physiological and
pathological phenomena, yet its structural basis is poorly understood. We determined the …

The α/β T cell receptor (TCR) HA1. 7 specific for the hemagglutinin (HA) antigen peptide
from influenza A virus is HLA-DR1 restricted but cross-reactive for the HA peptide presented …

A recent workshop discussed the recognition of multiple distinct ligands by individual T cell
and B cell receptors and the implications of this discovery for lymphocyte biology. The …

γδ T cells contribute to host immune competence uniquely. This is most likely because they
have distinctive antigen‐recognition properties. While the basic organization of γδ T‐cell …