Although metabolic alterations have been observed in cancer for almost a century, only
recently have the mechanisms underlying these changes been identified and the …

Defects in apoptosis underpin both tumorigenesis and drug resistance, and because of
these defects chemotherapy often fails. Understanding the molecular events that contribute …

The p53 tumor suppressor acts to integrate multiple stress signals into a series of diverse
antiproliferative responses. One of the most important p53 functions is its ability to activate …

Doxorubicin (DOX), a widely used chemotherapeutic agent, exhibits cardiotoxicity as an
adverse side effect in cancer patients. DOX-mediated cardiomyopathy is linked to its ability …

Death-Associated Protein Kinase 1 (DAPK1) belongs to a family of five serine/threonine
(Ser/Thr) kinases that possess tumor suppressive function and also mediate a wide range of …

Induction of apoptosis is an essential function of p53 as a tumor suppressor. p53 can
activate its downstream targets in a sequence specific manner to induce apoptosis. Most …

Abstract p53-dependent apoptosis contributes to the side effects of cancer treatment, and
genetic or pharmacological inhibition of p53 function can increase normal tissue resistance …

Numerous observations indicate a strong link between chronic inflammation and cancer.
This link is supported by substantial experimental evidence indicating mutual negative …

Cisplatin, a commonly used antineoplastic agent, destroys the sensory hair cells in the
cochlear and vestibular system leading to irreversible hearing loss and balance problems …

As a master transcription factor in cellular responses to external stress, tumor suppressor
p53 is tightly regulated. Excessive p53 activity during myocardial ischemia causes …