A joint is the point of connection between two bones in our body. Inflammation of the joint
leads to several diseases, including osteoarthritis, which is the concern of this review …

Osteoarthritis (OA) is one of the most debilitating diseases and is associated with a high
personal and socioeconomic burden. So far, there is no therapy available that effectively …

Synovial joints are complex structures that enable normal locomotion. Following injury, they
undergo a series of changes, including a prevalent inflammatory response. This increases …

Complement activation is associated with common rheumatic diseases such as systemic
lupus erythematosus (SLE), rheumatoid arthritis (RA) and systemic vasculitis. Evidence …

Osteoarthritis (OA) is a disease of the whole joint organ, characterized by the loss of
cartilage, and structural changes in bone including the formation of osteophytes, causing …

The complement system is a part of the immune system and consists of multiple complement
components with biological functions such as defense against pathogens and …

Understanding the causality of the post-traumatic osteoarthritis (PTOA) disease process of
the knee joint is important for diagnosing early disease and developing new and effective …

Inflammatory changes are observed in affected joints of osteoarthritis (OA) patients and are
thought to be involved in the pathology that develops along OA progression. This narrative …

Abstract Purpose of the Review Mounting evidence supports a role of low-grade
inflammation in the pathophysiology of osteoarthritis (OA). We review and discuss the role of …

Inflammation plays a central role in the pathogenesis of knee PTOA after knee trauma. While
a comprehensive therapy capable of preventing or delaying post-traumatic osteoarthritis …