Due to the advantages in efficacy and safety compared with traditional chemotherapy drugs,
targeted therapeutic drugs have become mainstream cancer treatments. Since the first …

Anaplastic lymphoma kinase (ALK) is a validated molecular target in several ALK-
rearranged malignancies, including non–small cell lung cancer. However, the clinical …

The burgeoning field of anaplastic lymphoma kinase (ALK) in cancer encompasses many
cancer types, from very rare cancers to the more prevalent non-small-cell lung cancer …

Inflammatory myofibroblastic tumor (IMT) is a distinctive mesenchymal neoplasm
characterized by a spindle-cell proliferation with an inflammatory infiltrate. Approximately …

Pathology and Genetics of Head and Neck Tumoursis the latest volume in the new WHO
series, on histological and genetic typing of human tumours. This authoritative, concise …

Inflammatory myofibroblastic tumor (IMT) is a neoplasm of intermediate biologic potential. In
this study, we report a subset of IMTs with histologic atypia and/or clinical aggressiveness …

Tyrosine kinases are involved in the pathogenesis of most cancers. However, few tyrosine
kinases have been shown to have a well-defined pathogenetic role in lymphomas. The …

Inflammatory pseudotumour is a generic term applied to a variety of neoplastic and non-
neoplastic entities that share a common histological appearance, namely a cytologically …

Anaplastic lymphoma kinase was first described in 1994 as the NPM-ALK fusion protein that
is expressed in the majority of anaplastic large-cell lymphomas. ALK is a receptor protein …

RTKs (receptor tyrosine kinases) play important roles in cellular proliferation and
differentiation. In addition, RTKs reveal oncogenic potential when their kinase activities are …